Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386988949> ?p ?o ?g. }
- W4386988949 abstract "Abstract Vibrio α-hemolysins (αHLs) are β-pore-forming toxins secreted by Vibrio pathogens, crucial for the facilitation of bacterial infections through host cell lysis. These toxins are produced as inactive precursors, requiring proteolytic maturation and membrane association for activation within host tissues. Here, we investigate Vibrio campbellii αHL (VcαHL), and establish that its hemolytic activity is significantly stimulated by calcium ions, with an EC 50 that aligns with physiological calcium concentrations. Furthermore, we illustrate the vital contribution of calcium ions to the oligomerization of VcαHL on membranes. Using X-ray crystallography and cryo-electron microscopy, we decipher both the immature and assembled structures of VcαHL and elucidate the conformational changes corresponding to toxin assembly. We also identify a calcium-binding module that is integral for VcαHL’s calcium-dependent activation. These findings provide insights into the regulatory mechanisms of VcαHL and have the potential to inform the development of targeted therapeutic strategies against Vibrio infections." @default.
- W4386988949 created "2023-09-24" @default.
- W4386988949 creator A5012107721 @default.
- W4386988949 creator A5017745174 @default.
- W4386988949 creator A5026945448 @default.
- W4386988949 creator A5028750403 @default.
- W4386988949 creator A5030262495 @default.
- W4386988949 creator A5050058428 @default.
- W4386988949 creator A5052134746 @default.
- W4386988949 creator A5059839779 @default.
- W4386988949 date "2023-09-23" @default.
- W4386988949 modified "2023-10-15" @default.
- W4386988949 title "Structural basis for calcium-stimulating pore formation of Vibrio α-hemolysin" @default.
- W4386988949 cites W1528643934 @default.
- W4386988949 cites W1542001620 @default.
- W4386988949 cites W1558207034 @default.
- W4386988949 cites W1787248566 @default.
- W4386988949 cites W1968029848 @default.
- W4386988949 cites W1968535358 @default.
- W4386988949 cites W1968889490 @default.
- W4386988949 cites W1971078428 @default.
- W4386988949 cites W1975661657 @default.
- W4386988949 cites W1990173904 @default.
- W4386988949 cites W1997219876 @default.
- W4386988949 cites W1997769724 @default.
- W4386988949 cites W1998133307 @default.
- W4386988949 cites W1999247237 @default.
- W4386988949 cites W2016607365 @default.
- W4386988949 cites W2018441039 @default.
- W4386988949 cites W2027283953 @default.
- W4386988949 cites W2030683115 @default.
- W4386988949 cites W2034509070 @default.
- W4386988949 cites W2035899761 @default.
- W4386988949 cites W2036145275 @default.
- W4386988949 cites W2043901383 @default.
- W4386988949 cites W2052589789 @default.
- W4386988949 cites W2065152402 @default.
- W4386988949 cites W2068119233 @default.
- W4386988949 cites W2073592717 @default.
- W4386988949 cites W2080500233 @default.
- W4386988949 cites W2086004174 @default.
- W4386988949 cites W2087693946 @default.
- W4386988949 cites W2092469188 @default.
- W4386988949 cites W2092545763 @default.
- W4386988949 cites W2100455255 @default.
- W4386988949 cites W2123109660 @default.
- W4386988949 cites W2131777290 @default.
- W4386988949 cites W2144081223 @default.
- W4386988949 cites W2165109084 @default.
- W4386988949 cites W2180229411 @default.
- W4386988949 cites W2195753589 @default.
- W4386988949 cites W2241777333 @default.
- W4386988949 cites W2296261650 @default.
- W4386988949 cites W2409887094 @default.
- W4386988949 cites W2494433368 @default.
- W4386988949 cites W2496298880 @default.
- W4386988949 cites W2522408089 @default.
- W4386988949 cites W2553299322 @default.
- W4386988949 cites W2587625522 @default.
- W4386988949 cites W2588988567 @default.
- W4386988949 cites W2589875042 @default.
- W4386988949 cites W2593511418 @default.
- W4386988949 cites W2614431660 @default.
- W4386988949 cites W2791354025 @default.
- W4386988949 cites W2818491996 @default.
- W4386988949 cites W2899714098 @default.
- W4386988949 cites W2953320394 @default.
- W4386988949 cites W2960693125 @default.
- W4386988949 cites W2970227777 @default.
- W4386988949 cites W3005798318 @default.
- W4386988949 cites W3083406432 @default.
- W4386988949 cites W3202614044 @default.
- W4386988949 cites W4220672023 @default.
- W4386988949 cites W4255760236 @default.
- W4386988949 cites W4255965156 @default.
- W4386988949 cites W4322501724 @default.
- W4386988949 doi "https://doi.org/10.1038/s41467-023-41579-x" @default.
- W4386988949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37741869" @default.
- W4386988949 hasPublicationYear "2023" @default.
- W4386988949 type Work @default.
- W4386988949 citedByCount "0" @default.
- W4386988949 crossrefType "journal-article" @default.
- W4386988949 hasAuthorship W4386988949A5012107721 @default.
- W4386988949 hasAuthorship W4386988949A5017745174 @default.
- W4386988949 hasAuthorship W4386988949A5026945448 @default.
- W4386988949 hasAuthorship W4386988949A5028750403 @default.
- W4386988949 hasAuthorship W4386988949A5030262495 @default.
- W4386988949 hasAuthorship W4386988949A5050058428 @default.
- W4386988949 hasAuthorship W4386988949A5052134746 @default.
- W4386988949 hasAuthorship W4386988949A5059839779 @default.
- W4386988949 hasBestOaLocation W43869889491 @default.
- W4386988949 hasConcept C104317684 @default.
- W4386988949 hasConcept C12554922 @default.
- W4386988949 hasConcept C136139683 @default.
- W4386988949 hasConcept C178790620 @default.
- W4386988949 hasConcept C181199279 @default.
- W4386988949 hasConcept C185592680 @default.
- W4386988949 hasConcept C2776154503 @default.
- W4386988949 hasConcept C2776993315 @default.
- W4386988949 hasConcept C2993175405 @default.