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• W4386989059 abstract "Abstract Influenza B viruses (IBV) can cause severe disease and death much like influenza A viruses (IAV), with a disproportionate number of infections in children. Despite moving to a quadrivalent vaccine to include strains from both the B/Victoria and B/Yamagata lineages, vaccine effectiveness rates continue to be variable and low in many past seasons. To develop more effective influenza B virus vaccines, three novel IBV hemagglutinin (HA) vaccines were designed using a computationally optimized broadly reactive antigen (COBRA) methodology. These IBV HA proteins were expressed on the surface of a virus-like particle (VLP) and used to vaccinate ferrets that were pre-immune to historical B/Victoria or B/Yamagata lineage viruses. Ferrets vaccinated with B-COBRA HA vaccines had neutralizing antibodies with high titer HAI titer against all influenza B viruses regardless of pre-immunization history. Conversely, VLPs expressing wild-type IBV HA antigens preferentially boosted titers against viruses from the same lineage and there was little-to-no seroprotective antibodies detected in ferrets with mismatched IBV pre-immune infections. Overall, a single IBV HA developed using the COBRA methodology elicited protective broadly-reactive antibodies against current and future drifted IBVs from both lineages." @default.
• W4386989059 created "2023-09-24" @default.
• W4386989059 creator A5033890850 @default.
• W4386989059 creator A5062233994 @default.
• W4386989059 date "2023-09-23" @default.
• W4386989059 modified "2023-09-27" @default.
• W4386989059 title "A computationally optimized broadly reactive hemagglutinin vaccine elicits neutralizing antibodies against influenza B viruses from both lineages" @default.
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• W4386989059 doi "https://doi.org/10.1038/s41598-023-43003-2" @default.
• W4386989059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37741893" @default.
• W4386989059 hasPublicationYear "2023" @default.
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