Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386989123> ?p ?o ?g. }
- W4386989123 endingPage "146243" @default.
- W4386989123 startingPage "146243" @default.
- W4386989123 abstract "Nano zero-valent iron (nZVI) assisted anaerobic digestion (AD) is considered an effective approach for mediating antibiotic resistance genes (ARGs) dissemination in activated sludge. However, little is known about the mechanisms that drive antibiotic resistomes evolution in relation with their physiological roles distinct from protection of bacteria against antimicrobials. Metagenomic sequencing showed that efflux pumps and rRNA methyltransferase genes were the most prevalent ARGs in anaerobes, being responsible for the variations of antibiotic resistome upon nZVI addition. Particularly, to withstand the oxidative stimuli derived from initially 9 days nZVI exposure, genes involved in the two component systems (PhoRB, BaeSR, EvgSA) and global regulator networks (MarA, SoxS) were increased, activating the chromosomally encoded intrinsic efflux pumps expression. Furthermore, to benefit for survival, the polyspecific efflux pumps were involved in the microbial physiological adaptations of enhanced siderophores, lipid moieties, and quorum sensing molecules exportation, which induced the adaptative efflux pumps expression. On the other hand, to maintain the protein synthesis under oxidative condition, genes encoding Rsm, Erm, and Rlu family methyltransferases were notably up-regulated via horizontal transfer, inducing the acquired rRNA methylation resistance. Importantly, after prolonged exposure to nZVI for 18 and 27 days, the antibiotic resistomes were measurably decreased, due to the recovered oxidative state and increased membrane rigidity. Overall, these findings provide a deep understanding on the necessity of antibiotic resistome evolution for anaerobes to adapt to nZVI exposure for survival, which can be introduced to improve the ARGs risks analysis." @default.
- W4386989123 created "2023-09-24" @default.
- W4386989123 creator A5004431227 @default.
- W4386989123 creator A5022847318 @default.
- W4386989123 creator A5027576668 @default.
- W4386989123 creator A5073501391 @default.
- W4386989123 creator A5082443250 @default.
- W4386989123 date "2023-11-01" @default.
- W4386989123 modified "2023-10-16" @default.
- W4386989123 title "The polyspecificity and adaptability of multidrug resistance shaped the antibiotic resistome in anaerobic digestion amended by nZVI: Evidence from efflux pumps and rRNA methyltransferase genes" @default.
- W4386989123 cites W1971925522 @default.
- W4386989123 cites W1972497570 @default.
- W4386989123 cites W1992069798 @default.
- W4386989123 cites W1995274825 @default.
- W4386989123 cites W2004696942 @default.
- W4386989123 cites W2016059809 @default.
- W4386989123 cites W2054114849 @default.
- W4386989123 cites W2065652119 @default.
- W4386989123 cites W2070760655 @default.
- W4386989123 cites W2098708380 @default.
- W4386989123 cites W2107022335 @default.
- W4386989123 cites W2111678991 @default.
- W4386989123 cites W2117615478 @default.
- W4386989123 cites W2134382101 @default.
- W4386989123 cites W2149144044 @default.
- W4386989123 cites W2150193089 @default.
- W4386989123 cites W2170830249 @default.
- W4386989123 cites W2180746523 @default.
- W4386989123 cites W2279840711 @default.
- W4386989123 cites W2332738150 @default.
- W4386989123 cites W2342392842 @default.
- W4386989123 cites W2615062474 @default.
- W4386989123 cites W2640916770 @default.
- W4386989123 cites W2756936050 @default.
- W4386989123 cites W2804102163 @default.
- W4386989123 cites W2884666999 @default.
- W4386989123 cites W2911949268 @default.
- W4386989123 cites W2912678136 @default.
- W4386989123 cites W2972068110 @default.
- W4386989123 cites W2974300351 @default.
- W4386989123 cites W3013548651 @default.
- W4386989123 cites W3022233374 @default.
- W4386989123 cites W3023054720 @default.
- W4386989123 cites W3081081200 @default.
- W4386989123 cites W3082923013 @default.
- W4386989123 cites W3101657268 @default.
- W4386989123 cites W3107714826 @default.
- W4386989123 cites W3125845881 @default.
- W4386989123 cites W3134469058 @default.
- W4386989123 cites W3136200508 @default.
- W4386989123 cites W3158875798 @default.
- W4386989123 cites W3161320421 @default.
- W4386989123 cites W3163451148 @default.
- W4386989123 cites W3173333347 @default.
- W4386989123 cites W3184296771 @default.
- W4386989123 cites W3201467445 @default.
- W4386989123 cites W3205631375 @default.
- W4386989123 cites W4229041439 @default.
- W4386989123 cites W4252747144 @default.
- W4386989123 cites W4377927188 @default.
- W4386989123 doi "https://doi.org/10.1016/j.cej.2023.146243" @default.
- W4386989123 hasPublicationYear "2023" @default.
- W4386989123 type Work @default.
- W4386989123 citedByCount "0" @default.
- W4386989123 crossrefType "journal-article" @default.
- W4386989123 hasAuthorship W4386989123A5004431227 @default.
- W4386989123 hasAuthorship W4386989123A5022847318 @default.
- W4386989123 hasAuthorship W4386989123A5027576668 @default.
- W4386989123 hasAuthorship W4386989123A5073501391 @default.
- W4386989123 hasAuthorship W4386989123A5082443250 @default.
- W4386989123 hasConcept C104317684 @default.
- W4386989123 hasConcept C200082930 @default.
- W4386989123 hasConcept C2776650774 @default.
- W4386989123 hasConcept C2776666601 @default.
- W4386989123 hasConcept C33288867 @default.
- W4386989123 hasConcept C501593827 @default.
- W4386989123 hasConcept C523546767 @default.
- W4386989123 hasConcept C54355233 @default.
- W4386989123 hasConcept C55493867 @default.
- W4386989123 hasConcept C86803240 @default.
- W4386989123 hasConcept C89423630 @default.
- W4386989123 hasConcept C91965660 @default.
- W4386989123 hasConcept C94665300 @default.
- W4386989123 hasConceptScore W4386989123C104317684 @default.
- W4386989123 hasConceptScore W4386989123C200082930 @default.
- W4386989123 hasConceptScore W4386989123C2776650774 @default.
- W4386989123 hasConceptScore W4386989123C2776666601 @default.
- W4386989123 hasConceptScore W4386989123C33288867 @default.
- W4386989123 hasConceptScore W4386989123C501593827 @default.
- W4386989123 hasConceptScore W4386989123C523546767 @default.
- W4386989123 hasConceptScore W4386989123C54355233 @default.
- W4386989123 hasConceptScore W4386989123C55493867 @default.
- W4386989123 hasConceptScore W4386989123C86803240 @default.
- W4386989123 hasConceptScore W4386989123C89423630 @default.
- W4386989123 hasConceptScore W4386989123C91965660 @default.
- W4386989123 hasConceptScore W4386989123C94665300 @default.
- W4386989123 hasLocation W43869891231 @default.
- W4386989123 hasOpenAccess W4386989123 @default.