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• W4386989206 abstract "Neuron-specific enolase (NSE), which is a highly specific marker for neurons, could be a predictor for the prognosis in symptomatic intracranial haemorrhage patients with acute ischaemic stroke, who are receiving endovascular treatment. This study aimed to investigate the relationship between NSE and symptomatic intracranial haemorrhage (sICH) in patients with acute anterior circulation stroke undergoing endovascular treatment.A total of 215 consecutive patients with acute stroke treated with endovascular treatment (EVT) were included.Patients with stroke and acute anterior circulation occlusion, receiving endovascular treatment treated at our Hospital were enrolled between January 2017 and August 2021. NSE was measured on arrival at the neurology intensive care unit after EVT. The patients were divided into two groups according to whether symptomatic intracranial haemorrhage was present. Univariate and multivariate analyses were performed. NSE was also incorporated into the Thrombolysis in Cerebral Ischaemia Score, Alberta Stroke Program Early CT Score, and Glucose Level(TAG) score, which was developed as a scoring system to predict symptomatic intracranial haemorrhage, and the prediction capability was compared with the TAG score alone.Causal inference was performed using the package dowhy in Python to evaluate causal relationship between NSE and sICH.The Area Under The Curve(AUC) value of NSE showed moderate accuracy, with an AUC value of 0.729 (95% CI 0.655∼0.795,P<0.001). The NSE cut-off value was set at 23.88 ng/ml. When the NSE ≥ 23.88 ng/ml, the sensitivity was 58.33%, and the specificity was 78.72% (P<0.001). The AUC for the TAG+NSE score was 0.801 compared with an AUC of 0.632 for the TAG score (Z=2.034, P=0.042). A causal inference model(CIM) using the DoWhy library shows a proportional relationship between NSE and the diagnosis of sICH.This study is the first to demonstrate that elevated NSE is an independent predictor of symptomatic intracranial haemorrhage in patients with acute anterior circulation stroke who are undergoing endovascular treatment." @default.
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• W4386989206 date "2023-09-01" @default.
• W4386989206 modified "2023-10-15" @default.
• W4386989206 title "Elevated Neuron-specific Enolase Predicts Symptomatic Intracranial Haemorrhage in Ischaemic Stroke Patients Treated with Endovascular Treatment" @default.
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• W4386989206 doi "https://doi.org/10.1016/j.wneu.2023.09.065" @default.
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• W4386989206 hasPublicationYear "2023" @default.
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