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• W4386989298 endingPage "104991" @default.
• W4386989298 startingPage "104991" @default.
• W4386989298 abstract "Patients with chronic conditions often need to adhere to long-term medication regimens, requiring them to take medication daily for an extended period. Nevertheless, the requirement of daily dosing can contribute to treatment non-adherence, potentially leading to the reoccurrence of the underlying conditions. Moreover, the poor water solubility of certain molecules poses a significant challenge in the development of effective pharmaceutical drug formulations. It is also challenging that many newly developed drugs exhibit limited solubility in organic media as well. As a result, poorly water-soluble drugs often present problems such as unpredictable absorption patterns and low systemic bioavailability. In such cases parenteral drug delivery systems offer promising prospects such as an improved absorption profile of the drug, leading to enhanced bioavailability. Moreover, due to the limited solubility, it is impractical and potentially hazardous to administer them intravenously as solutions; because there is a risk of precipitation and vessel blockage. Additionally, formulating a suitable parenteral drug delivery system is already a challenging endeavor, and when combined with the presence of poorly water-soluble new chemical entities, the complexity of the task is further enhanced. Therefore, in designing of microemulsion (ME) for the parenteral delivery of the drug, utilizing an appropriate surfactant not only enhances the solubility of the drug but also facilitates improved permeability across cell membranes. Therefore, exploiting the advantages of ME opens new possibilities for harnessing the potential benefits of BCS-II, BCS-III and BCS-IV drugs. MEs are basically stable mixtures consisting of two immiscible liquids, stabilized by surfactants and potentially other compounds. They are thermodynamically stable, transparent, and isotropic, meaning they have a uniform composition throughout. Also, in the current scenario The ME has been applicable for ease of administration, spontaneous formulation, and easy manufacturing scale-up, to maintain the thermodynamic stability of the drug and improve drug solubilization without affecting the shelf-life and bioavailability of the drug. The sME following the parenteral route has a wide range of applications to treat prevalent diseases such as cancer, autoimmune disease, infectious disease, cardiovascular disease, and many more. In this review article, we have discussed applications of ME by emphasizing the focus on parenteral administration. Along with that, future challenges are also elucidated in the manuscript." @default.
• W4386989298 created "2023-09-24" @default.
• W4386989298 creator A5006661257 @default.
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• W4386989298 creator A5085446980 @default.
• W4386989298 creator A5085972944 @default.
• W4386989298 date "2023-11-01" @default.
• W4386989298 modified "2023-10-15" @default.
• W4386989298 title "Parenteral microemulsion for drug delivery: Advances and update" @default.
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