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- W4386989371 endingPage "105614" @default.
- W4386989371 startingPage "105614" @default.
- W4386989371 abstract "Alzheimer's disease (AD) is an age-related neurodegenerative disorder (NDD). In the central nervous system (CNS), immune cells like microglia could reprogram intracellular metabolism to alter or exert cellular immune functions in response to environmental stimuli. In AD, microglia could be activated and differentiated into pro-inflammatory or anti-inflammatory phenotypes, and these differences in cellular phenotypes resulted in variance in cellular energy metabolism. Considering the enormous energy requirement of microglia for immune functions, the changes in mitochondria-centered energy metabolism and substrates of microglia are crucial for the cellular regulation of immune responses. Here we reviewed the mechanisms of microglial metabolic reprogramming by analyzing their flexible metabolic patterns and changes that occurred in their metabolism during the development of AD. Further, we summarized the role of drugs in modulating immunometabolic reprogramming to prevent neuroinflammation, which may shed light on a new research direction for AD treatment." @default.
- W4386989371 created "2023-09-24" @default.
- W4386989371 creator A5027721660 @default.
- W4386989371 creator A5042930225 @default.
- W4386989371 creator A5043398762 @default.
- W4386989371 creator A5091168431 @default.
- W4386989371 date "2023-12-01" @default.
- W4386989371 modified "2023-10-11" @default.
- W4386989371 title "The immunometabolic reprogramming of microglia in Alzheimerʼs disease" @default.
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