Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386989391> ?p ?o ?g. }
- W4386989391 endingPage "100405" @default.
- W4386989391 startingPage "100405" @default.
- W4386989391 abstract "Sofosbuvir (SOF) is an anti-HCV (Hepatitis C Virus) used as an off-label drug in treating COVID-19 and the usage requires good therapeutic drug monitoring, with analytical and suitable sample preparation methods. Therefore, this research aimed to apply in silico and laboratory testing in preparing SOF molecularly imprinted polymers (MIP). MIP is expected to improve sample preparation performance. The best functional monomer and porogen selection were determined through the use of Density Functional Theory (DFT) method with the B3LYP basis set 6-31G (d,p) and molecular dynamics simulation. The association constant test and Jobs plot were determined by the UV spectrophotometry and MIP synthesis method was conducted by bulk and precipitation polymerization. The polymer particles underwent characterization using Fourier-transform infrared spectroscopy and scanning electron microscopy. The result showed that methacrylic acid (MAA) and acetonitrile were the best functional monomer and porogen for synthesis. Precipitation polymerization yielded superior outcomes in terms of polymer homogeneity and adsorption capability compared to bulk polymerization. Polymer, MIP B, with a composition ratio of template:functional monomer:cross-linkers = 1:1:20, which was synthesized by the precipitation method, provided the best adsorption capability in all solvents tested, and had an imprinting factor of 1.15." @default.
- W4386989391 created "2023-09-24" @default.
- W4386989391 creator A5029200178 @default.
- W4386989391 creator A5032572627 @default.
- W4386989391 creator A5040175516 @default.
- W4386989391 creator A5056132834 @default.
- W4386989391 date "2023-10-01" @default.
- W4386989391 modified "2023-10-17" @default.
- W4386989391 title "Study on monomer functional suitability toward sofosbuvir in molecularly imprinted polymer: In silico and experimental study" @default.
- W4386989391 cites W1234792450 @default.
- W4386989391 cites W151483826 @default.
- W4386989391 cites W1644081035 @default.
- W4386989391 cites W1718144579 @default.
- W4386989391 cites W1865949808 @default.
- W4386989391 cites W1914356530 @default.
- W4386989391 cites W1975130005 @default.
- W4386989391 cites W2057096801 @default.
- W4386989391 cites W2060412662 @default.
- W4386989391 cites W2083556162 @default.
- W4386989391 cites W2119536455 @default.
- W4386989391 cites W2120894192 @default.
- W4386989391 cites W2199277977 @default.
- W4386989391 cites W2207523426 @default.
- W4386989391 cites W2229869676 @default.
- W4386989391 cites W2250552629 @default.
- W4386989391 cites W2282122952 @default.
- W4386989391 cites W2398819820 @default.
- W4386989391 cites W2467855691 @default.
- W4386989391 cites W2477971233 @default.
- W4386989391 cites W2521292982 @default.
- W4386989391 cites W2548526484 @default.
- W4386989391 cites W2605521640 @default.
- W4386989391 cites W2750259103 @default.
- W4386989391 cites W2891762220 @default.
- W4386989391 cites W2942472798 @default.
- W4386989391 cites W2967793308 @default.
- W4386989391 cites W2984110273 @default.
- W4386989391 cites W3014306719 @default.
- W4386989391 cites W3020568147 @default.
- W4386989391 cites W3021638978 @default.
- W4386989391 cites W3034992442 @default.
- W4386989391 cites W3123302916 @default.
- W4386989391 cites W3127113483 @default.
- W4386989391 cites W3139393703 @default.
- W4386989391 cites W3178804580 @default.
- W4386989391 cites W3196223483 @default.
- W4386989391 cites W3201552719 @default.
- W4386989391 cites W3209041045 @default.
- W4386989391 cites W3211507287 @default.
- W4386989391 cites W4205469406 @default.
- W4386989391 cites W4205858825 @default.
- W4386989391 cites W4281636747 @default.
- W4386989391 cites W578073291 @default.
- W4386989391 doi "https://doi.org/10.1016/j.jcomc.2023.100405" @default.
- W4386989391 hasPublicationYear "2023" @default.
- W4386989391 type Work @default.
- W4386989391 citedByCount "0" @default.
- W4386989391 crossrefType "journal-article" @default.
- W4386989391 hasAuthorship W4386989391A5029200178 @default.
- W4386989391 hasAuthorship W4386989391A5032572627 @default.
- W4386989391 hasAuthorship W4386989391A5040175516 @default.
- W4386989391 hasAuthorship W4386989391A5056132834 @default.
- W4386989391 hasBestOaLocation W43869893911 @default.
- W4386989391 hasConcept C111998727 @default.
- W4386989391 hasConcept C118792377 @default.
- W4386989391 hasConcept C127413603 @default.
- W4386989391 hasConcept C150394285 @default.
- W4386989391 hasConcept C159985019 @default.
- W4386989391 hasConcept C160892712 @default.
- W4386989391 hasConcept C161790260 @default.
- W4386989391 hasConcept C162602672 @default.
- W4386989391 hasConcept C166940927 @default.
- W4386989391 hasConcept C178790620 @default.
- W4386989391 hasConcept C185592680 @default.
- W4386989391 hasConcept C192562407 @default.
- W4386989391 hasConcept C2775968528 @default.
- W4386989391 hasConcept C42360764 @default.
- W4386989391 hasConcept C44228677 @default.
- W4386989391 hasConcept C521977710 @default.
- W4386989391 hasConcept C53856295 @default.
- W4386989391 hasConcept C90958600 @default.
- W4386989391 hasConceptScore W4386989391C111998727 @default.
- W4386989391 hasConceptScore W4386989391C118792377 @default.
- W4386989391 hasConceptScore W4386989391C127413603 @default.
- W4386989391 hasConceptScore W4386989391C150394285 @default.
- W4386989391 hasConceptScore W4386989391C159985019 @default.
- W4386989391 hasConceptScore W4386989391C160892712 @default.
- W4386989391 hasConceptScore W4386989391C161790260 @default.
- W4386989391 hasConceptScore W4386989391C162602672 @default.
- W4386989391 hasConceptScore W4386989391C166940927 @default.
- W4386989391 hasConceptScore W4386989391C178790620 @default.
- W4386989391 hasConceptScore W4386989391C185592680 @default.
- W4386989391 hasConceptScore W4386989391C192562407 @default.
- W4386989391 hasConceptScore W4386989391C2775968528 @default.
- W4386989391 hasConceptScore W4386989391C42360764 @default.
- W4386989391 hasConceptScore W4386989391C44228677 @default.
- W4386989391 hasConceptScore W4386989391C521977710 @default.
- W4386989391 hasConceptScore W4386989391C53856295 @default.