Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386989559> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4386989559 endingPage "712" @default.
- W4386989559 startingPage "707" @default.
- W4386989559 abstract "Myeloid leukemia 1 (MCL-1), a BCL-2 protein family member, acts as an anti-apoptotic protein by interacting with pro-apoptotic BCL-2 proteins. Its overexpression is frequently observed in numerous cancer types including breast cancer, and is closely linked to the initiation and progression of tumors as well as poor prognosis and resistance to therapeutic interventions. Here, a database of 3402 chemicals with established therapeutic activity against various diseases was chosen and systematically screened against the MCL-1 protein. Visual inspection and binding energy analysis revealed that the compounds OSU-03012, Raltitrexed, Ostarine (MK-2866), Dovitinib (TKI-258), and Varespladib (LY315920) had strong binding affinity for the MCL-1 protein. Notably, their binding affinity was higher than that of the control compounds. These compounds exhibited strong interactions with critical amino acid residues of the MCL-1 protein. Furthermore, these compounds shared several common amino acid residue interactions with the control compounds. These findings suggest that these compounds may be useful as MCL-1 inhibitors in the treatment of breast cancer. However, additional experimental validation is required to confirm these findings." @default.
- W4386989559 created "2023-09-24" @default.
- W4386989559 creator A5025038048 @default.
- W4386989559 date "2023-06-30" @default.
- W4386989559 modified "2023-10-18" @default.
- W4386989559 title "Molecular docking analysis of MCL-1 inhibitors for breast cancer management" @default.
- W4386989559 doi "https://doi.org/10.6026/97320630019707" @default.
- W4386989559 hasPublicationYear "2023" @default.
- W4386989559 type Work @default.
- W4386989559 citedByCount "0" @default.
- W4386989559 crossrefType "journal-article" @default.
- W4386989559 hasAuthorship W4386989559A5025038048 @default.
- W4386989559 hasBestOaLocation W43869895591 @default.
- W4386989559 hasConcept C104317684 @default.
- W4386989559 hasConcept C11804247 @default.
- W4386989559 hasConcept C121608353 @default.
- W4386989559 hasConcept C126322002 @default.
- W4386989559 hasConcept C159110408 @default.
- W4386989559 hasConcept C167625842 @default.
- W4386989559 hasConcept C185592680 @default.
- W4386989559 hasConcept C2994376932 @default.
- W4386989559 hasConcept C41685203 @default.
- W4386989559 hasConcept C502942594 @default.
- W4386989559 hasConcept C515207424 @default.
- W4386989559 hasConcept C530470458 @default.
- W4386989559 hasConcept C55493867 @default.
- W4386989559 hasConcept C71924100 @default.
- W4386989559 hasConceptScore W4386989559C104317684 @default.
- W4386989559 hasConceptScore W4386989559C11804247 @default.
- W4386989559 hasConceptScore W4386989559C121608353 @default.
- W4386989559 hasConceptScore W4386989559C126322002 @default.
- W4386989559 hasConceptScore W4386989559C159110408 @default.
- W4386989559 hasConceptScore W4386989559C167625842 @default.
- W4386989559 hasConceptScore W4386989559C185592680 @default.
- W4386989559 hasConceptScore W4386989559C2994376932 @default.
- W4386989559 hasConceptScore W4386989559C41685203 @default.
- W4386989559 hasConceptScore W4386989559C502942594 @default.
- W4386989559 hasConceptScore W4386989559C515207424 @default.
- W4386989559 hasConceptScore W4386989559C530470458 @default.
- W4386989559 hasConceptScore W4386989559C55493867 @default.
- W4386989559 hasConceptScore W4386989559C71924100 @default.
- W4386989559 hasIssue "6" @default.
- W4386989559 hasLocation W43869895591 @default.
- W4386989559 hasOpenAccess W4386989559 @default.
- W4386989559 hasPrimaryLocation W43869895591 @default.
- W4386989559 hasRelatedWork W2134700052 @default.
- W4386989559 hasRelatedWork W2466762323 @default.
- W4386989559 hasRelatedWork W2611084861 @default.
- W4386989559 hasRelatedWork W2748952813 @default.
- W4386989559 hasRelatedWork W2802206763 @default.
- W4386989559 hasRelatedWork W2899084033 @default.
- W4386989559 hasRelatedWork W3095611878 @default.
- W4386989559 hasRelatedWork W4382135385 @default.
- W4386989559 hasRelatedWork W4386741862 @default.
- W4386989559 hasRelatedWork W47810773 @default.
- W4386989559 hasVolume "19" @default.
- W4386989559 isParatext "false" @default.
- W4386989559 isRetracted "false" @default.
- W4386989559 workType "article" @default.