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- W4386993278 abstract "Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord dysfunction in the aging population. Significant neurological deficits may result from a delayed diagnosis as well as inadequate neurological recovery following surgical decompression. Here, we review the pathophysiology of DCM with an emphasis on how blood-spinal cord barrier (BSCB) disruption is a critical yet neglected pathological feature affecting prognosis. In patients suffering from DCM, compromise of the BSCB is evidenced by elevated cerebrospinal fluid (CSF) to serum protein ratios and abnormal contrast-enhancement upon magnetic resonance imaging (MRI). In animal model correlates, there is histological evidence of increased extravasation of tissue dyes and serum contents, and pathological changes to the neurovascular unit. BSCB dysfunction is the likely culprit for ischemia-reperfusion injury following surgical decompression, which can result in devastating neurological sequelae. As there are currently no therapeutic approaches specifically targeting BSCB reconstitution, we conclude the review by discussing potential interventions harnessed for this purpose." @default.
- W4386993278 created "2023-09-25" @default.
- W4386993278 creator A5008383067 @default.
- W4386993278 creator A5019230524 @default.
- W4386993278 creator A5042083053 @default.
- W4386993278 date "2023-09-25" @default.
- W4386993278 modified "2023-10-12" @default.
- W4386993278 title "Blood-spinal cord barrier disruption in degenerative cervical myelopathy" @default.
- W4386993278 cites W1501888058 @default.
- W4386993278 cites W1502955608 @default.
- W4386993278 cites W1545901128 @default.
- W4386993278 cites W1566189373 @default.
- W4386993278 cites W1595354421 @default.
- W4386993278 cites W1699362631 @default.
- W4386993278 cites W1777981398 @default.
- W4386993278 cites W182730751 @default.
- W4386993278 cites W1840306665 @default.
- W4386993278 cites W1862139915 @default.
- W4386993278 cites W1905312869 @default.
- W4386993278 cites W1908112684 @default.
- W4386993278 cites W1911832415 @default.
- W4386993278 cites W1927190926 @default.
- W4386993278 cites W1966645588 @default.
- W4386993278 cites W1968758728 @default.
- W4386993278 cites W1969102065 @default.
- W4386993278 cites W1970940868 @default.
- W4386993278 cites W1971798829 @default.
- W4386993278 cites W1972817664 @default.
- W4386993278 cites W1973786451 @default.
- W4386993278 cites W1975117257 @default.
- W4386993278 cites W1976037108 @default.
- W4386993278 cites W1981425827 @default.
- W4386993278 cites W1983227054 @default.
- W4386993278 cites W1987270591 @default.
- W4386993278 cites W1988273800 @default.
- W4386993278 cites W1989441840 @default.
- W4386993278 cites W1990788679 @default.
- W4386993278 cites W1993064394 @default.
- W4386993278 cites W1993910212 @default.
- W4386993278 cites W1994336923 @default.
- W4386993278 cites W1996554590 @default.
- W4386993278 cites W1998099768 @default.
- W4386993278 cites W1998770595 @default.
- W4386993278 cites W1999174228 @default.
- W4386993278 cites W1999783884 @default.
- W4386993278 cites W2004370075 @default.
- W4386993278 cites W2004967267 @default.
- W4386993278 cites W2009317405 @default.
- W4386993278 cites W2009340953 @default.
- W4386993278 cites W2010430324 @default.
- W4386993278 cites W2012225058 @default.
- W4386993278 cites W2012458146 @default.
- W4386993278 cites W2012586386 @default.
- W4386993278 cites W2013224564 @default.
- W4386993278 cites W2020061739 @default.
- W4386993278 cites W2020547407 @default.
- W4386993278 cites W2025847070 @default.
- W4386993278 cites W2029561126 @default.
- W4386993278 cites W2030445380 @default.
- W4386993278 cites W2034049482 @default.
- W4386993278 cites W2034098691 @default.
- W4386993278 cites W2034380071 @default.
- W4386993278 cites W2043748208 @default.
- W4386993278 cites W2044606851 @default.
- W4386993278 cites W2048085214 @default.
- W4386993278 cites W2049166107 @default.
- W4386993278 cites W2049362565 @default.
- W4386993278 cites W2049958331 @default.
- W4386993278 cites W2051449032 @default.
- W4386993278 cites W2052874642 @default.
- W4386993278 cites W2054508930 @default.
- W4386993278 cites W20548302 @default.
- W4386993278 cites W2055429754 @default.
- W4386993278 cites W2056372586 @default.
- W4386993278 cites W2056856515 @default.
- W4386993278 cites W2060061409 @default.
- W4386993278 cites W2060393760 @default.
- W4386993278 cites W2061428463 @default.
- W4386993278 cites W2062371022 @default.
- W4386993278 cites W2065262203 @default.
- W4386993278 cites W2067219797 @default.
- W4386993278 cites W2068251212 @default.
- W4386993278 cites W2068750445 @default.
- W4386993278 cites W2069781018 @default.
- W4386993278 cites W2070185756 @default.
- W4386993278 cites W2071491701 @default.
- W4386993278 cites W2073154435 @default.
- W4386993278 cites W2075546094 @default.
- W4386993278 cites W2077055706 @default.
- W4386993278 cites W2078097009 @default.
- W4386993278 cites W2078495649 @default.
- W4386993278 cites W2078613707 @default.
- W4386993278 cites W2079529443 @default.
- W4386993278 cites W2080079643 @default.
- W4386993278 cites W2080353159 @default.
- W4386993278 cites W2083938228 @default.
- W4386993278 cites W2086892345 @default.
- W4386993278 cites W2087375743 @default.
- W4386993278 cites W2088226547 @default.
- W4386993278 cites W2091391030 @default.