Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386993791> ?p ?o ?g. }
- W4386993791 abstract "Nitric oxide (NO) plays several distinct roles in endothelial homeostasis. Except for activating the guanylyl cyclase enzyme-dependent cyclic guanosine monophosphate signaling pathway, NO can bind reactive cysteine residues in target proteins, a process known as S-nitrosylation (SNO). S-nitrosylation is proposed to explain the multiple biological functions of NO in the endothelium. Investigating the targets and mechanism of protein SNO in endothelial cells (ECs) can provide new strategies for treating endothelial dysfunction-related diseases.In response to different environments, proteomics has identified multiple SNO targets in ECs. Functional studies confirm that SNO regulates NO bioavailability, inflammation, permeability, oxidative stress, mitochondrial function, and insulin sensitivity in ECs. It also influences endothelial cell proliferation, migration, apoptosis, and transdifferentiation.Single-cell transcriptomic analysis of endothelial cells isolated from different mouse tissues showed heterogeneous gene signatures. However, litter research focuses on the heterogeneous properties of SNO proteins in ECs derived from different tissue. Although metabolism reprogramming plays a vital role in endothelial functions, little is known about how protein SNO regulates metabolism reprogramming in ECs.Precisely deciphering the effects of protein SNO in ECs isolated from different tissues under different conditions is necessary to further characterize the relationship between protein SNO and endothelial dysfunction-related diseases. In addition, identifying SNO targets that can influence endothelial metabolic reprogramming and the underlying mechanism can offer new views on the crosstalk between metabolism and post-translational protein modification." @default.
- W4386993791 created "2023-09-25" @default.
- W4386993791 creator A5025618652 @default.
- W4386993791 creator A5046489385 @default.
- W4386993791 creator A5056184390 @default.
- W4386993791 creator A5061581501 @default.
- W4386993791 creator A5069290077 @default.
- W4386993791 creator A5079594267 @default.
- W4386993791 creator A5090381708 @default.
- W4386993791 date "2023-09-24" @default.
- W4386993791 modified "2023-09-30" @default.
- W4386993791 title "Roles of Protein S-Nitrosylation in Endothelial Homeostasis and Dysfunction" @default.
- W4386993791 cites W1447783661 @default.
- W4386993791 cites W1492554664 @default.
- W4386993791 cites W1531685626 @default.
- W4386993791 cites W1553299262 @default.
- W4386993791 cites W1555938743 @default.
- W4386993791 cites W1583601846 @default.
- W4386993791 cites W1607892649 @default.
- W4386993791 cites W164205712 @default.
- W4386993791 cites W1812961065 @default.
- W4386993791 cites W1942154378 @default.
- W4386993791 cites W1964993651 @default.
- W4386993791 cites W1966322594 @default.
- W4386993791 cites W1969645870 @default.
- W4386993791 cites W1971950783 @default.
- W4386993791 cites W1979069114 @default.
- W4386993791 cites W1979763991 @default.
- W4386993791 cites W1981695365 @default.
- W4386993791 cites W1982203562 @default.
- W4386993791 cites W1983668987 @default.
- W4386993791 cites W1984601537 @default.
- W4386993791 cites W1988873174 @default.
- W4386993791 cites W1992254322 @default.
- W4386993791 cites W1993164953 @default.
- W4386993791 cites W1993429855 @default.
- W4386993791 cites W1995150314 @default.
- W4386993791 cites W1997023449 @default.
- W4386993791 cites W1998905001 @default.
- W4386993791 cites W1999772557 @default.
- W4386993791 cites W2000075945 @default.
- W4386993791 cites W2001461795 @default.
- W4386993791 cites W2003683297 @default.
- W4386993791 cites W2003946735 @default.
- W4386993791 cites W2003996544 @default.
- W4386993791 cites W2004175200 @default.
- W4386993791 cites W2004351327 @default.
- W4386993791 cites W2006958729 @default.
- W4386993791 cites W2007281248 @default.
- W4386993791 cites W2017712812 @default.
- W4386993791 cites W2018053075 @default.
- W4386993791 cites W2021117769 @default.
- W4386993791 cites W2026585864 @default.
- W4386993791 cites W2026759679 @default.
- W4386993791 cites W2026908253 @default.
- W4386993791 cites W2031847165 @default.
- W4386993791 cites W2032227357 @default.
- W4386993791 cites W2033040828 @default.
- W4386993791 cites W2035508242 @default.
- W4386993791 cites W2041729846 @default.
- W4386993791 cites W2048946982 @default.
- W4386993791 cites W2049226881 @default.
- W4386993791 cites W2052689575 @default.
- W4386993791 cites W2054027791 @default.
- W4386993791 cites W2055157881 @default.
- W4386993791 cites W2055502644 @default.
- W4386993791 cites W2058520514 @default.
- W4386993791 cites W2061010923 @default.
- W4386993791 cites W2065220292 @default.
- W4386993791 cites W2065773243 @default.
- W4386993791 cites W2066601649 @default.
- W4386993791 cites W2066649179 @default.
- W4386993791 cites W2068427129 @default.
- W4386993791 cites W2071293996 @default.
- W4386993791 cites W2071705315 @default.
- W4386993791 cites W2072463503 @default.
- W4386993791 cites W2075443461 @default.
- W4386993791 cites W2076253183 @default.
- W4386993791 cites W2078297328 @default.
- W4386993791 cites W2081518693 @default.
- W4386993791 cites W2082659541 @default.
- W4386993791 cites W2083311984 @default.
- W4386993791 cites W2083960240 @default.
- W4386993791 cites W2088729484 @default.
- W4386993791 cites W2090046344 @default.
- W4386993791 cites W2091380103 @default.
- W4386993791 cites W2095762161 @default.
- W4386993791 cites W2096000363 @default.
- W4386993791 cites W2096909791 @default.
- W4386993791 cites W2098805210 @default.
- W4386993791 cites W2100357323 @default.
- W4386993791 cites W2101457798 @default.
- W4386993791 cites W2102132700 @default.
- W4386993791 cites W2104790006 @default.
- W4386993791 cites W2106307355 @default.
- W4386993791 cites W2107366065 @default.
- W4386993791 cites W2108747532 @default.
- W4386993791 cites W2109692125 @default.
- W4386993791 cites W2110780888 @default.
- W4386993791 cites W2111871063 @default.