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- W4386996863 endingPage "6761" @default.
- W4386996863 startingPage "6761" @default.
- W4386996863 abstract "Substrate-controlled diversity-oriented synthesis of polycyclic frameworks via [4 + 2] and [3 + 2] annulations between ninhydrin-derived Morita-Baylis-Hillman (MBH) adducts and 3,4-dihydroisoquinolines under similar reaction conditions have been developed. The reaction provides diversity-oriented synthesis of a series of novel and structurally complex spiro multi heterocyclic skeletons in good yields (up to 87% and 90%, respectively) with excellent diastereoselectivities (up to >25:1 dr). In particular, the switchable [4 + 2] and [3 + 2] annulation reactions are controlled by tuning the hydroxyl protecting group on the ninhydrin-derived MBH adduct to deliver structural diverse spiro[indene-2,2'-[1,3]oxazino[2,3-a]isoquinoline] and spiro[indene-2,1'-pyrrolo[2,1-a]isoquinoline], respectively. Furthermore, the relative configuration and chemical structure of two kinds of cycloadducts were confirmed through X-ray diffraction analysis." @default.
- W4386996863 created "2023-09-25" @default.
- W4386996863 creator A5002671310 @default.
- W4386996863 creator A5008837809 @default.
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- W4386996863 creator A5051327026 @default.
- W4386996863 creator A5056493143 @default.
- W4386996863 creator A5057332153 @default.
- W4386996863 creator A5086043611 @default.
- W4386996863 date "2023-09-22" @default.
- W4386996863 modified "2023-10-18" @default.
- W4386996863 title "Substrate-Controlled Diversity-Oriented Synthesis of Novel Polycyclic Frameworks via [4 + 2] and [3 + 2] Annulations of Ninhydrin-Derived MBH Adducts with 3,4-Dihydroisoquinolines" @default.
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- W4386996863 doi "https://doi.org/10.3390/molecules28196761" @default.
- W4386996863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37836604" @default.
- W4386996863 hasPublicationYear "2023" @default.
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