Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386996864> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4386996864 endingPage "1851" @default.
- W4386996864 startingPage "1851" @default.
- W4386996864 abstract "ETV6::ABL1 gene fusion is a rare recurrent genomic rearrangement associated with hematologic malignancies, and frequently occurs with additional anomalies. Due to the opposite chromosome orientations of the ETV6 and ABL1 genes, an oncogenic in-frame ETV6::ABL1 gene fusion cannot be formed by a simple translocation. The molecular mechanism of the ETV6::ABL1 fusion and the significance of co-occurring anomalies are not fully understood. We characterized genomic alterations in an individual with ETV6::ABL1 gene-fusion-positive myeloid neoplasm using various genomic technologies. Our findings uncovered a molecular mechanism of the ETV6::ABL1 fusion, in which a paracentric inversion within the short arm of chromosome 12 (12p) and a translocation between the long arm of a chromosome 9 and the 12p with the inversion were involved. In addition, we detected multiple additional anomalies in the individual, and our findings suggested that the ETV6::ABL1 fusion occurred as a secondary event in a subset of cells with the additional anomalies. We speculate that the additional anomalies may predispose to further pathogenic changes, including ETV6::ABL1 fusion, leading to neoplastic transformation." @default.
- W4386996864 created "2023-09-25" @default.
- W4386996864 creator A5015115182 @default.
- W4386996864 creator A5058398688 @default.
- W4386996864 creator A5086408252 @default.
- W4386996864 creator A5091814150 @default.
- W4386996864 date "2023-09-23" @default.
- W4386996864 modified "2023-09-30" @default.
- W4386996864 title "Complex Genomic Rearrangements Involving ETV6::ABL1 Gene Fusion in an Individual with Myeloid Neoplasm" @default.
- W4386996864 cites W1965620518 @default.
- W4386996864 cites W1974664851 @default.
- W4386996864 cites W1985671514 @default.
- W4386996864 cites W2003546293 @default.
- W4386996864 cites W2013092140 @default.
- W4386996864 cites W2020391202 @default.
- W4386996864 cites W2023217887 @default.
- W4386996864 cites W2025881660 @default.
- W4386996864 cites W2029439166 @default.
- W4386996864 cites W2052091646 @default.
- W4386996864 cites W2063989268 @default.
- W4386996864 cites W2101436494 @default.
- W4386996864 cites W2104647405 @default.
- W4386996864 cites W2139739677 @default.
- W4386996864 cites W2145842725 @default.
- W4386996864 cites W2152987588 @default.
- W4386996864 cites W2157477905 @default.
- W4386996864 cites W2324755163 @default.
- W4386996864 cites W2397706354 @default.
- W4386996864 cites W2518143119 @default.
- W4386996864 cites W2529796347 @default.
- W4386996864 cites W2555393363 @default.
- W4386996864 cites W2770679231 @default.
- W4386996864 cites W2801770342 @default.
- W4386996864 cites W2933195911 @default.
- W4386996864 cites W2994258011 @default.
- W4386996864 cites W3015869041 @default.
- W4386996864 cites W3173694663 @default.
- W4386996864 cites W4381660968 @default.
- W4386996864 doi "https://doi.org/10.3390/genes14101851" @default.
- W4386996864 hasPublicationYear "2023" @default.
- W4386996864 type Work @default.
- W4386996864 citedByCount "0" @default.
- W4386996864 crossrefType "journal-article" @default.
- W4386996864 hasAuthorship W4386996864A5015115182 @default.
- W4386996864 hasAuthorship W4386996864A5058398688 @default.
- W4386996864 hasAuthorship W4386996864A5086408252 @default.
- W4386996864 hasAuthorship W4386996864A5091814150 @default.
- W4386996864 hasBestOaLocation W43869968641 @default.
- W4386996864 hasConcept C104317684 @default.
- W4386996864 hasConcept C111829193 @default.
- W4386996864 hasConcept C125418893 @default.
- W4386996864 hasConcept C138626823 @default.
- W4386996864 hasConcept C165984737 @default.
- W4386996864 hasConcept C2778274637 @default.
- W4386996864 hasConcept C2780833115 @default.
- W4386996864 hasConcept C2992511266 @default.
- W4386996864 hasConcept C30481170 @default.
- W4386996864 hasConcept C42362537 @default.
- W4386996864 hasConcept C502942594 @default.
- W4386996864 hasConcept C53226629 @default.
- W4386996864 hasConcept C54355233 @default.
- W4386996864 hasConcept C62478195 @default.
- W4386996864 hasConcept C86803240 @default.
- W4386996864 hasConceptScore W4386996864C104317684 @default.
- W4386996864 hasConceptScore W4386996864C111829193 @default.
- W4386996864 hasConceptScore W4386996864C125418893 @default.
- W4386996864 hasConceptScore W4386996864C138626823 @default.
- W4386996864 hasConceptScore W4386996864C165984737 @default.
- W4386996864 hasConceptScore W4386996864C2778274637 @default.
- W4386996864 hasConceptScore W4386996864C2780833115 @default.
- W4386996864 hasConceptScore W4386996864C2992511266 @default.
- W4386996864 hasConceptScore W4386996864C30481170 @default.
- W4386996864 hasConceptScore W4386996864C42362537 @default.
- W4386996864 hasConceptScore W4386996864C502942594 @default.
- W4386996864 hasConceptScore W4386996864C53226629 @default.
- W4386996864 hasConceptScore W4386996864C54355233 @default.
- W4386996864 hasConceptScore W4386996864C62478195 @default.
- W4386996864 hasConceptScore W4386996864C86803240 @default.
- W4386996864 hasIssue "10" @default.
- W4386996864 hasLocation W43869968641 @default.
- W4386996864 hasOpenAccess W4386996864 @default.
- W4386996864 hasPrimaryLocation W43869968641 @default.
- W4386996864 hasRelatedWork W1988225658 @default.
- W4386996864 hasRelatedWork W1990301753 @default.
- W4386996864 hasRelatedWork W2020391202 @default.
- W4386996864 hasRelatedWork W2023217887 @default.
- W4386996864 hasRelatedWork W2051966591 @default.
- W4386996864 hasRelatedWork W2172151766 @default.
- W4386996864 hasRelatedWork W2367903050 @default.
- W4386996864 hasRelatedWork W2395698070 @default.
- W4386996864 hasRelatedWork W3110854351 @default.
- W4386996864 hasRelatedWork W4386996864 @default.
- W4386996864 hasVolume "14" @default.
- W4386996864 isParatext "false" @default.
- W4386996864 isRetracted "false" @default.
- W4386996864 workType "article" @default.