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- W4386996885 startingPage "2369" @default.
- W4386996885 abstract "A series of new hybrid derivatives 1a–c, 2a–c, 3a–c, 4a–c, 5a–c, inspired by nature, were synthesized and studied as multifunctional agents for the treatment of Alzheimer’s disease (AD). These compounds were designed to merge together the trifluoromethyl benzyloxyaminic bioactive moiety, previously identified, with different acids available in nature. The ability of the synthesized compounds to chelate biometals, such as Cu2+, Zn2+ and Fe2+, was studied by UV–Vis spectrometer, and through a preliminary screening their antioxidant activity was evaluated by DPPH. Then, selected compounds were tested by in vitro ABTS free radical method and ex vivo rat brain TBARS assay. Compounds 2a–c, combining the strongest antioxidant and biometal chelators activities, were studied for their ability to contrast Aβ1-40 fibrillization process. Finally, starting from the promising profile obtained for compound 2a, we evaluated if it could be able to induce a positive cross-interaction between transthyretin (TTR) and Aβ in presence and in absence of Cu2+." @default.
- W4386996885 created "2023-09-25" @default.
- W4386996885 creator A5026065600 @default.
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- W4386996885 date "2023-09-22" @default.
- W4386996885 modified "2023-10-17" @default.
- W4386996885 title "New Hybrid Compounds Incorporating Natural Products as Multifunctional Agents against Alzheimer’s Disease" @default.
- W4386996885 cites W1597953055 @default.
- W4386996885 cites W1770473989 @default.
- W4386996885 cites W1967144890 @default.
- W4386996885 cites W1970144812 @default.
- W4386996885 cites W1971757965 @default.
- W4386996885 cites W1973166472 @default.
- W4386996885 cites W1975046995 @default.
- W4386996885 cites W1981702595 @default.
- W4386996885 cites W2010089695 @default.
- W4386996885 cites W2011540010 @default.
- W4386996885 cites W2012991711 @default.
- W4386996885 cites W2020677736 @default.
- W4386996885 cites W2022578673 @default.
- W4386996885 cites W2025125596 @default.
- W4386996885 cites W2026093597 @default.
- W4386996885 cites W2036379697 @default.
- W4386996885 cites W2048305209 @default.
- W4386996885 cites W2057698260 @default.
- W4386996885 cites W2080519444 @default.
- W4386996885 cites W2083500052 @default.
- W4386996885 cites W2101662524 @default.
- W4386996885 cites W2107491044 @default.
- W4386996885 cites W2151392910 @default.
- W4386996885 cites W2151431560 @default.
- W4386996885 cites W2162710350 @default.
- W4386996885 cites W2313985771 @default.
- W4386996885 cites W2316265097 @default.
- W4386996885 cites W2342805349 @default.
- W4386996885 cites W2344282546 @default.
- W4386996885 cites W2345936988 @default.
- W4386996885 cites W2394927848 @default.
- W4386996885 cites W2415830294 @default.
- W4386996885 cites W2514542546 @default.
- W4386996885 cites W2562384805 @default.
- W4386996885 cites W2594071428 @default.
- W4386996885 cites W2598074183 @default.
- W4386996885 cites W2620789908 @default.
- W4386996885 cites W2622854062 @default.
- W4386996885 cites W2758649116 @default.
- W4386996885 cites W2782806177 @default.
- W4386996885 cites W2791802747 @default.
- W4386996885 cites W2883098973 @default.
- W4386996885 cites W2891733579 @default.
- W4386996885 cites W2909437563 @default.
- W4386996885 cites W2915131983 @default.
- W4386996885 cites W2921692911 @default.
- W4386996885 cites W2937760380 @default.
- W4386996885 cites W2944150075 @default.
- W4386996885 cites W2952287055 @default.
- W4386996885 cites W2952701400 @default.
- W4386996885 cites W2954613999 @default.
- W4386996885 cites W2969839420 @default.
- W4386996885 cites W3004885960 @default.
- W4386996885 cites W3005458426 @default.
- W4386996885 cites W3005540971 @default.
- W4386996885 cites W3010127435 @default.
- W4386996885 cites W3011023105 @default.
- W4386996885 cites W3011051402 @default.
- W4386996885 cites W3011686755 @default.
- W4386996885 cites W3011725547 @default.
- W4386996885 cites W3015096020 @default.
- W4386996885 cites W3015298266 @default.
- W4386996885 cites W3027358274 @default.
- W4386996885 cites W3028423921 @default.
- W4386996885 cites W3036053671 @default.
- W4386996885 cites W3036123142 @default.
- W4386996885 cites W3037002398 @default.
- W4386996885 cites W3048109944 @default.
- W4386996885 cites W3086559466 @default.
- W4386996885 cites W3104465768 @default.
- W4386996885 cites W3123131964 @default.
- W4386996885 cites W3160076229 @default.
- W4386996885 cites W3162710586 @default.
- W4386996885 cites W3197343464 @default.
- W4386996885 cites W3201572544 @default.
- W4386996885 cites W3206867625 @default.
- W4386996885 cites W3213259336 @default.
- W4386996885 cites W4200390523 @default.
- W4386996885 cites W4211036635 @default.
- W4386996885 cites W4213120368 @default.
- W4386996885 cites W4214587366 @default.
- W4386996885 cites W4220827971 @default.