FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386997054> ?p ?o ?g. }

• W4386997054 endingPage "1989" @default.
• W4386997054 startingPage "1989" @default.
• W4386997054 abstract "The hepatitis E virus (HEV) is increasingly acknowledged as the primary cause of acute hepatitis. While most HEV infections are self-limiting, cases of chronic infection and fulminant hepatitis necessitate the administration of anti-HEV medications. However, there is a lack of specific antiviral drugs designed for HEV, and the currently available drug (ribavirin) has been associated with significant adverse effects. The development of innovative antiviral drugs involves targeting distinct steps within the viral life cycle: the early step (attachment and internalization), middle step (translation and RNA replication), and late step (virus particle formation and virion release). We recently established three HEV reporter systems, each covering one or two of these steps. Using these reporter systems, we identified various potential drug candidates that target different steps of the HEV life cycle. Through rigorous in vitro testing using our robust cell culture system with the genotype 3 HEV strain (JE03-1760F/P10), we confirmed the efficacy of these drugs, when used alone or in combination with existing anti-HEV drugs. This underscores their significance in the quest for an effective anti-HEV treatment. In the present review, we discuss the development of the three reporter systems, their applications in drug screening, and their potential to advance our understanding of the incompletely elucidated HEV life cycle." @default.
• W4386997054 created "2023-09-25" @default.
• W4386997054 creator A5016027987 @default.
• W4386997054 creator A5028710783 @default.
• W4386997054 creator A5039347513 @default.
• W4386997054 creator A5053315666 @default.
• W4386997054 date "2023-09-23" @default.
• W4386997054 modified "2023-10-14" @default.
• W4386997054 title "Three Distinct Reporter Systems of Hepatitis E Virus and Their Utility as Drug Screening Platforms" @default.
• W4386997054 cites W1664373451 @default.
• W4386997054 cites W1763495789 @default.
• W4386997054 cites W1784269859 @default.
• W4386997054 cites W1974705246 @default.
• W4386997054 cites W1979342543 @default.
• W4386997054 cites W1981129051 @default.
• W4386997054 cites W1983290734 @default.
• W4386997054 cites W1984974182 @default.
• W4386997054 cites W1987085726 @default.
• W4386997054 cites W1987962702 @default.
• W4386997054 cites W2001057158 @default.
• W4386997054 cites W2003597182 @default.
• W4386997054 cites W2006079477 @default.
• W4386997054 cites W2011009266 @default.
• W4386997054 cites W2012382212 @default.
• W4386997054 cites W2017436619 @default.
• W4386997054 cites W2020181437 @default.
• W4386997054 cites W2025897959 @default.
• W4386997054 cites W2032567331 @default.
• W4386997054 cites W2037821649 @default.
• W4386997054 cites W2042060358 @default.
• W4386997054 cites W2046513349 @default.
• W4386997054 cites W2047910097 @default.
• W4386997054 cites W2048392344 @default.
• W4386997054 cites W2051594149 @default.
• W4386997054 cites W2059565467 @default.
• W4386997054 cites W2067431728 @default.
• W4386997054 cites W2070539427 @default.
• W4386997054 cites W2071540837 @default.
• W4386997054 cites W2090697124 @default.
• W4386997054 cites W2090786883 @default.
• W4386997054 cites W2090927051 @default.
• W4386997054 cites W2106146897 @default.
• W4386997054 cites W2108466588 @default.
• W4386997054 cites W2123700681 @default.
• W4386997054 cites W2124045778 @default.
• W4386997054 cites W2124460108 @default.
• W4386997054 cites W2127163853 @default.
• W4386997054 cites W2129076367 @default.
• W4386997054 cites W2136334851 @default.
• W4386997054 cites W2137955827 @default.
• W4386997054 cites W2147089201 @default.
• W4386997054 cites W2149419398 @default.
• W4386997054 cites W2156176404 @default.
• W4386997054 cites W2169333888 @default.
• W4386997054 cites W2194518191 @default.
• W4386997054 cites W2220354224 @default.
• W4386997054 cites W2261822942 @default.
• W4386997054 cites W2325427926 @default.
• W4386997054 cites W2333163669 @default.
• W4386997054 cites W2335301902 @default.
• W4386997054 cites W2347059170 @default.
• W4386997054 cites W2415496653 @default.
• W4386997054 cites W2477762964 @default.
• W4386997054 cites W2528181301 @default.
• W4386997054 cites W2540897471 @default.
• W4386997054 cites W2571372048 @default.
• W4386997054 cites W2578489854 @default.
• W4386997054 cites W2624766447 @default.
• W4386997054 cites W2750684049 @default.
• W4386997054 cites W2754886024 @default.
• W4386997054 cites W2757632046 @default.
• W4386997054 cites W2766206172 @default.
• W4386997054 cites W2794804312 @default.
• W4386997054 cites W2800061958 @default.
• W4386997054 cites W2802664161 @default.
• W4386997054 cites W2894871538 @default.
• W4386997054 cites W2899989846 @default.
• W4386997054 cites W2900890523 @default.
• W4386997054 cites W2909023913 @default.
• W4386997054 cites W2939822128 @default.
• W4386997054 cites W2945992828 @default.
• W4386997054 cites W2962634872 @default.
• W4386997054 cites W2966845728 @default.
• W4386997054 cites W2967934792 @default.
• W4386997054 cites W2976307912 @default.
• W4386997054 cites W2993062243 @default.
• W4386997054 cites W2997526712 @default.
• W4386997054 cites W3001522500 @default.
• W4386997054 cites W3026530948 @default.
• W4386997054 cites W3048066941 @default.
• W4386997054 cites W3095941939 @default.
• W4386997054 cites W3112039569 @default.
• W4386997054 cites W3112509806 @default.
• W4386997054 cites W3135231239 @default.
• W4386997054 cites W3150120446 @default.
• W4386997054 cites W3161663242 @default.
• W4386997054 cites W3174083855 @default.
• W4386997054 cites W4200352292 @default.

• next