FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386998311> ?p ?o ?g. }

• W4386998311 endingPage "215" @default.
• W4386998311 startingPage "215" @default.
• W4386998311 abstract "The occurrence and development of chronic obstructive pulmonary disease (COPD) are regulated by environmental and genetic factors. In hypoxia, Erythropoietin (EPO) satisfies the body's need for oxygen by promoting the production of red blood cells. Hypoxia was proven to be a common physiological condition in COPD progression and associated with many complications. Some studies have found that EPO is involved in the development of COPD. But the mechanism has not been fully proven.We conducted a case-control study enrolled 1095 COPD patients and 1144 healthy controls in Guangdong Province to evaluate the association between EPO polymorphisms (rs1617640 A>C, rs507392 A>G, rs564449 G>T) and COPD susceptibility. 872 participants from southern Gansu Province were recruited to verify the effect of EPO polymorphisms on lung function.EPO rs1617640 C allele reduced COPD susceptibility in southern Chinese significantly (AC vs. AA: adjusted Odds ratio (OR) = 0.805, 95% CI = 0.669-0.969; AC+CC vs. AA: adjusted OR = 0.822, 95% CI = 0.689-0.980). However, there was no association between rs507392 A>G and rs564449 G>T polymorphisms and COPD susceptibility (p > 0.05). We further observed that the rs1617640 C allele was associated with higher FEV1 and FVC in Guangdong and Gansu populations significantly (both p < 0.05). In brief, the level of FEV1 and FVC increased with the C allele number. We modeled the relative risk for men and women, in which the population-attributable risks chances were 0.449 (0.258-0.641) and 0.262 (0.128-0.396) respectively. In this model, smoking status, coal as fuels, education level, and rs1617640 A>C were finally retained for males, while smoking status, biomass as fuels, and1617640 A>C were retained for females. In the end, using the method developed by Gail and Bruzzi, we fitted a 10-year absolute risk model for southern Chinese with different individual relative risks, which was presented as a table.In conclusion, this study found that EPO rs1617640 A>C polymorphism is associated with COPD susceptibility in southern Chinese, and the C allele was associated with better lung function. In addition, it could also be considered a genetic marker associated with environmental factors to predict the absolute 10-year risk of COPD in southern Chinese." @default.
• W4386998311 created "2023-09-25" @default.
• W4386998311 creator A5015158690 @default.
• W4386998311 creator A5016506157 @default.
• W4386998311 creator A5021540642 @default.
• W4386998311 creator A5024709912 @default.
• W4386998311 creator A5036492073 @default.
• W4386998311 creator A5040009629 @default.
• W4386998311 creator A5041325363 @default.
• W4386998311 creator A5048995364 @default.
• W4386998311 creator A5055551738 @default.
• W4386998311 creator A5064840609 @default.
• W4386998311 creator A5069174552 @default.
• W4386998311 creator A5080916162 @default.
• W4386998311 creator A5085060684 @default.
• W4386998311 creator A5086586768 @default.
• W4386998311 date "2023-09-24" @default.
• W4386998311 modified "2023-10-12" @default.
• W4386998311 title "EPO rs1617640 A>C is a Protective Factor for Chronic Obstructive Pulmonary Disease: A Case Control Study" @default.
• W4386998311 doi "https://doi.org/10.31083/j.fbl2809215" @default.
• W4386998311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37796693" @default.
• W4386998311 hasPublicationYear "2023" @default.
• W4386998311 type Work @default.
• W4386998311 citedByCount "0" @default.
• W4386998311 crossrefType "journal-article" @default.
• W4386998311 hasAuthorship W4386998311A5015158690 @default.
• W4386998311 hasAuthorship W4386998311A5016506157 @default.
• W4386998311 hasAuthorship W4386998311A5021540642 @default.
• W4386998311 hasAuthorship W4386998311A5024709912 @default.
• W4386998311 hasAuthorship W4386998311A5036492073 @default.
• W4386998311 hasAuthorship W4386998311A5040009629 @default.
• W4386998311 hasAuthorship W4386998311A5041325363 @default.
• W4386998311 hasAuthorship W4386998311A5048995364 @default.
• W4386998311 hasAuthorship W4386998311A5055551738 @default.
• W4386998311 hasAuthorship W4386998311A5064840609 @default.
• W4386998311 hasAuthorship W4386998311A5069174552 @default.
• W4386998311 hasAuthorship W4386998311A5080916162 @default.
• W4386998311 hasAuthorship W4386998311A5085060684 @default.
• W4386998311 hasAuthorship W4386998311A5086586768 @default.
• W4386998311 hasBestOaLocation W43869983111 @default.
• W4386998311 hasConcept C104317684 @default.
• W4386998311 hasConcept C126322002 @default.
• W4386998311 hasConcept C146304588 @default.
• W4386998311 hasConcept C156957248 @default.
• W4386998311 hasConcept C178790620 @default.
• W4386998311 hasConcept C180754005 @default.
• W4386998311 hasConcept C185592680 @default.
• W4386998311 hasConcept C2776780178 @default.
• W4386998311 hasConcept C2778534260 @default.
• W4386998311 hasConcept C2779134260 @default.
• W4386998311 hasConcept C2908647359 @default.
• W4386998311 hasConcept C540031477 @default.
• W4386998311 hasConcept C54355233 @default.
• W4386998311 hasConcept C67636389 @default.
• W4386998311 hasConcept C71924100 @default.
• W4386998311 hasConcept C7836513 @default.
• W4386998311 hasConcept C86803240 @default.
• W4386998311 hasConcept C90924648 @default.
• W4386998311 hasConcept C99454951 @default.
• W4386998311 hasConceptScore W4386998311C104317684 @default.
• W4386998311 hasConceptScore W4386998311C126322002 @default.
• W4386998311 hasConceptScore W4386998311C146304588 @default.
• W4386998311 hasConceptScore W4386998311C156957248 @default.
• W4386998311 hasConceptScore W4386998311C178790620 @default.
• W4386998311 hasConceptScore W4386998311C180754005 @default.
• W4386998311 hasConceptScore W4386998311C185592680 @default.
• W4386998311 hasConceptScore W4386998311C2776780178 @default.
• W4386998311 hasConceptScore W4386998311C2778534260 @default.
• W4386998311 hasConceptScore W4386998311C2779134260 @default.
• W4386998311 hasConceptScore W4386998311C2908647359 @default.
• W4386998311 hasConceptScore W4386998311C540031477 @default.
• W4386998311 hasConceptScore W4386998311C54355233 @default.
• W4386998311 hasConceptScore W4386998311C67636389 @default.
• W4386998311 hasConceptScore W4386998311C71924100 @default.
• W4386998311 hasConceptScore W4386998311C7836513 @default.
• W4386998311 hasConceptScore W4386998311C86803240 @default.
• W4386998311 hasConceptScore W4386998311C90924648 @default.
• W4386998311 hasConceptScore W4386998311C99454951 @default.
• W4386998311 hasIssue "9" @default.
• W4386998311 hasLocation W43869983111 @default.
• W4386998311 hasLocation W43869983112 @default.
• W4386998311 hasOpenAccess W4386998311 @default.
• W4386998311 hasPrimaryLocation W43869983111 @default.
• W4386998311 hasRelatedWork W1588725841 @default.
• W4386998311 hasRelatedWork W1592859225 @default.
• W4386998311 hasRelatedWork W1602405375 @default.
• W4386998311 hasRelatedWork W2033945997 @default.
• W4386998311 hasRelatedWork W2085281796 @default.
• W4386998311 hasRelatedWork W2179797810 @default.
• W4386998311 hasRelatedWork W2333298519 @default.
• W4386998311 hasRelatedWork W2386195037 @default.
• W4386998311 hasRelatedWork W2415995798 @default.
• W4386998311 hasRelatedWork W4256664370 @default.
• W4386998311 hasVolume "28" @default.
• W4386998311 isParatext "false" @default.
• W4386998311 isRetracted "false" @default.
• W4386998311 workType "article" @default.