FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387002015> ?p ?o ?g. }

• W4387002015 endingPage "10" @default.
• W4387002015 startingPage "1" @default.
• W4387002015 abstract "<b><i>Introduction:</i></b> Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) and responsive neurostimulation (RNS) of the hippocampus are the predominant approaches to brain stimulation for treating mesial temporal lobe epilepsy (MTLE). Both are similarly effective at reducing seizures in drug-resistant patients, but the underlying mechanisms are poorly understood. In rare cases where it is clinically indicated to use RNS and DBS simultaneously, ambulatory electrophysiology from RNS may provide the opportunity to measure the effects of ANT DBS in the putative seizure onset zone and identify biomarkers associated with clinical improvement. Here, one such patient became seizure free, allowing us to identify and compare the changes in hippocampal electrophysiology associated with ANT stimulation and seizure freedom. <b><i>Methods:</i></b> Ambulatory electrocorticography and clinical history were retrospectively analyzed for a patient treated with RNS and DBS for MTLE. DBS artifacts were used to identify ANT stimulation periods on RNS recordings and measure peri-stimulus electrographic changes. Clinical history was used to determine the chronic electrographic changes associated with seizure freedom. <b><i>Results:</i></b> ANT stimulation acutely suppressed hippocampal gamma (25–90Hz) power, with minimal theta (4–8Hz) suppression and without clear effects on seizure frequency. Eventually, the patient became seizure free alongside the emergence of chronic gamma increase and theta suppression, which started at the same time as clobazam was introduced. Both seizure freedom and the associated electrophysiology persisted after inadvertent DBS discontinuation, further implicating the clobazam relationship. Unexpectedly, RNS detections and long episodes increased, although they were not considered to be electrographic seizures, and the patient remained clinically seizure free. <b><i>Conclusion:</i></b> ANT stimulation and seizure freedom were associated with distinct, dissimilar spectral changes in RNS-derived electrophysiology. The time course of these changes supported a new medication as the most likely cause of clinical improvement. Broadly, this work showcases the use of RNS recordings to interpret the effects of multimodal therapy. Specifically, it lends additional credence to hippocampal theta suppression as a biomarker previously associated with seizure reduction in RNS patients." @default.
• W4387002015 created "2023-09-26" @default.
• W4387002015 creator A5013078223 @default.
• W4387002015 creator A5018739410 @default.
• W4387002015 creator A5034257495 @default.
• W4387002015 creator A5049441810 @default.
• W4387002015 creator A5067215919 @default.
• W4387002015 date "2023-09-22" @default.
• W4387002015 modified "2023-10-12" @default.
• W4387002015 title "Distinct Biomarkers of ANT Stimulation and Seizure Freedom in an Epilepsy Patient with Ambulatory Hippocampal Electrocorticography" @default.
• W4387002015 cites W1978747821 @default.
• W4387002015 cites W1989017031 @default.
• W4387002015 cites W2038606869 @default.
• W4387002015 cites W2135629133 @default.
• W4387002015 cites W2158334924 @default.
• W4387002015 cites W2164207469 @default.
• W4387002015 cites W2472563750 @default.
• W4387002015 cites W2607074866 @default.
• W4387002015 cites W2890412233 @default.
• W4387002015 cites W2901578692 @default.
• W4387002015 cites W2901619576 @default.
• W4387002015 cites W2947016468 @default.
• W4387002015 cites W2991234053 @default.
• W4387002015 cites W2996413851 @default.
• W4387002015 cites W3000215627 @default.
• W4387002015 cites W3007790220 @default.
• W4387002015 cites W3028550789 @default.
• W4387002015 cites W3039019953 @default.
• W4387002015 cites W3044132865 @default.
• W4387002015 cites W3151064539 @default.
• W4387002015 cites W3176400723 @default.
• W4387002015 cites W4282962429 @default.
• W4387002015 doi "https://doi.org/10.1159/000533680" @default.
• W4387002015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37742626" @default.
• W4387002015 hasPublicationYear "2023" @default.
• W4387002015 type Work @default.
• W4387002015 citedByCount "0" @default.
• W4387002015 crossrefType "journal-article" @default.
• W4387002015 hasAuthorship W4387002015A5013078223 @default.
• W4387002015 hasAuthorship W4387002015A5018739410 @default.
• W4387002015 hasAuthorship W4387002015A5034257495 @default.
• W4387002015 hasAuthorship W4387002015A5049441810 @default.
• W4387002015 hasAuthorship W4387002015A5067215919 @default.
• W4387002015 hasConcept C126322002 @default.
• W4387002015 hasConcept C148762608 @default.
• W4387002015 hasConcept C15744967 @default.
• W4387002015 hasConcept C169760540 @default.
• W4387002015 hasConcept C24998067 @default.
• W4387002015 hasConcept C2778186239 @default.
• W4387002015 hasConcept C2778542668 @default.
• W4387002015 hasConcept C2779134260 @default.
• W4387002015 hasConcept C2779734285 @default.
• W4387002015 hasConcept C2780117969 @default.
• W4387002015 hasConcept C2781161787 @default.
• W4387002015 hasConcept C42219234 @default.
• W4387002015 hasConcept C522805319 @default.
• W4387002015 hasConcept C71924100 @default.
• W4387002015 hasConceptScore W4387002015C126322002 @default.
• W4387002015 hasConceptScore W4387002015C148762608 @default.
• W4387002015 hasConceptScore W4387002015C15744967 @default.
• W4387002015 hasConceptScore W4387002015C169760540 @default.
• W4387002015 hasConceptScore W4387002015C24998067 @default.
• W4387002015 hasConceptScore W4387002015C2778186239 @default.
• W4387002015 hasConceptScore W4387002015C2778542668 @default.
• W4387002015 hasConceptScore W4387002015C2779134260 @default.
• W4387002015 hasConceptScore W4387002015C2779734285 @default.
• W4387002015 hasConceptScore W4387002015C2780117969 @default.
• W4387002015 hasConceptScore W4387002015C2781161787 @default.
• W4387002015 hasConceptScore W4387002015C42219234 @default.
• W4387002015 hasConceptScore W4387002015C522805319 @default.
• W4387002015 hasConceptScore W4387002015C71924100 @default.
• W4387002015 hasLocation W43870020151 @default.
• W4387002015 hasLocation W43870020152 @default.
• W4387002015 hasOpenAccess W4387002015 @default.
• W4387002015 hasPrimaryLocation W43870020151 @default.
• W4387002015 hasRelatedWork W17166845 @default.
• W4387002015 hasRelatedWork W2061706623 @default.
• W4387002015 hasRelatedWork W2067046547 @default.
• W4387002015 hasRelatedWork W2079245438 @default.
• W4387002015 hasRelatedWork W2086943057 @default.
• W4387002015 hasRelatedWork W2186758735 @default.
• W4387002015 hasRelatedWork W2391750868 @default.
• W4387002015 hasRelatedWork W2519119624 @default.
• W4387002015 hasRelatedWork W3198339856 @default.
• W4387002015 hasRelatedWork W622158969 @default.
• W4387002015 isParatext "false" @default.
• W4387002015 isRetracted "false" @default.
• W4387002015 workType "article" @default.