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- W4387002023 abstract "Alu hypomethylation is a common epigenetic process that promotes genomic instability with aging phenotypes, which leads to type 2 diabetes mellitus (type 2 DM). Previously, our results showed significantly decreased Alu methylation levels in type 2 DM patients. In this study, we aimed to investigate the longitudinal changes in Alu methylation levels in these patients.We observed significantly decreased Alu methylation levels in type 2 DM patients compared with normal (p = 0.0462). Moreover, our findings demonstrated changes in Alu hypomethylation over a follow-up period within the same individuals (p < 0.0001). A reduction in Alu methylation was found in patients with increasing HbA1c levels (p = 0.0013) and directly correlated with increased HbA1c levels in type 2 DM patients (r = -0.2273, p = 0.0387).Alu methylation in type 2 DM patients progressively decreases with increasing HbA1c levels. This observation suggests a potential association between Alu hypomethylation and the underlying molecular mechanisms of elevated blood glucose. Furthermore, monitoring Alu methylation levels may serve as a valuable biomarker for assessing the clinical outcomes of type 2 DM." @default.
- W4387002023 created "2023-09-26" @default.
- W4387002023 creator A5021302353 @default.
- W4387002023 creator A5036834118 @default.
- W4387002023 date "2023-09-24" @default.
- W4387002023 modified "2023-10-01" @default.
- W4387002023 title "Decreased Alu methylation in type 2 diabetes mellitus patients increases <scp>HbA1c</scp> levels" @default.
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- W4387002023 doi "https://doi.org/10.1002/jcla.24966" @default.
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