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- W4387002786 abstract "The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of allergy-protective Clostridia that contribute to their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole (a ligand for the aryl hydrocarbon receptor [AhR]). Lysates and flagella from a Clostridia consortium induced interleukin-22 (IL-22) secretion from ileal explants. IL-22 production is abrogated in explants from mice in which TLR5 or MyD88 signaling is deficient either globally or conditionally in CD11c+ antigen-presenting cells. AhR signaling in RORγt+ cells is necessary for the induction of IL-22. Mice deficient in AhR in RORγt+ cells exhibit increased intestinal permeability and are more susceptible to an anaphylactic response to food. Our findings implicate TLR5 and AhR signaling in a molecular mechanism by which commensal Clostridia protect against allergic responses to food." @default.
- W4387002786 created "2023-09-26" @default.
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- W4387002786 date "2023-10-01" @default.
- W4387002786 modified "2023-10-01" @default.
- W4387002786 title "Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food" @default.
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- W4387002786 doi "https://doi.org/10.1016/j.celrep.2023.113153" @default.
- W4387002786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37742185" @default.