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- W4387002851 abstract "Ferroptosis is a newly identified myocardial cell death mechanism driven by iron-dependent lipid peroxidation. The presence of elevated intramyocardial lipid levels and excessive iron in diabetic patients suggest a predominant role of ferroptosis in diabetic cardiomyopathy. Since myocardial cell death is a precursor of heart failure and intensive glycemic control cannot abate the increased risk of heart failure in diabetic patients, targeting myocardial cell death via ferroptosis is a promising therapeutic avenue to prevent and/or treat diabetic cardiomyopathy. This review presents updated and comprehensive knowledge on mechanisms underpinning ferroptosis, clarifies several misconceptions about ferroptosis, emphasizes the importance of ferroptosis in diabetes-induced myocardial cell death, and offers valuable approaches to evaluate and target ferroptosis in the diabetic heart. Furthermore, basic concepts and ideas rendered in this review, including glutathione peroxidase-4-independent and mitochondrial mechanisms of ferroptosis, are also critical for investigating ferroptosis in other diabetic organs, as well as non-diabetic and metabolically compromised hearts." @default.
- W4387002851 created "2023-09-26" @default.
- W4387002851 creator A5040349597 @default.
- W4387002851 creator A5055086761 @default.
- W4387002851 date "2023-09-25" @default.
- W4387002851 modified "2023-10-01" @default.
- W4387002851 title "Ironing Out the Details: Ferroptosis and its Relevance to Diabetic Cardiomyopathy" @default.
- W4387002851 doi "https://doi.org/10.1152/ajpregu.00117.2023" @default.
- W4387002851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37746707" @default.
- W4387002851 hasPublicationYear "2023" @default.
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