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- W4387003040 abstract "E-cadherin-catenin complex together with the cytoskeleton, builds the core of Adherens junctions (AJs). It has been reported that Scribble stabilizes the coupling of E-cadherin with catenins promoting epithelial cell adhesion, but the mechanism remains unknown. We show that Scribble, Lgl1, and NMII-A reside in a complex with E-cadherin-catenin complex. Depletion of either Scribble or Lgl1 disrupts the localization of E-cadherin-catenin complex to AJs. aPKCζ phosphorylation of Lgl1 regulates AJ localization of Lgl1 and E-cadherin-catenin complexes. Both Scribble and Lgl1 regulate the activation and recruitment of NMII-A at AJs. Finally, Scribble and Lgl1 are downregulated by TGFβ-induced EMT, and their re-expression during EMT impedes its progression. Our results provide insight into the mechanism regulating AJ integrity by Scribble, Lgl1, and NMII-A." @default.
- W4387003040 created "2023-09-26" @default.
- W4387003040 creator A5005731505 @default.
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- W4387003040 creator A5092932648 @default.
- W4387003040 date "2023-09-24" @default.
- W4387003040 modified "2023-10-06" @default.
- W4387003040 title "Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity" @default.
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- W4387003040 doi "https://doi.org/10.1080/19336918.2023.2260645" @default.
- W4387003040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37743653" @default.
- W4387003040 hasPublicationYear "2023" @default.
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