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• W4387004224 abstract "Abstract The determinants of severe disease caused by West Nile virus (WNV) and why only ~1% of individuals progress to encephalitis remain poorly understood. Here, we use human and mouse enteroids, and a mouse model of pathogenesis, to explore the capacity of WNV to directly infect gastrointestinal (GI) tract cells and contribute to disease severity. At baseline, WNV poorly infects human and mouse enteroid cultures and enterocytes in mice. However, when STAT1 or type I interferon (IFN) responses are absent, GI tract cells become infected, and this is associated with augmented GI tract and blood-brain barrier (BBB) permeability, accumulation of gut-derived molecules in the brain, and more severe WNV disease. The increased gut permeability requires TNF-α signaling, and is absent in WNV-infected IFN-deficient germ-free mice. To link these findings to human disease, we measured auto-antibodies against type I IFNs in serum from WNV-infected human cohorts. A greater frequency of auto- and neutralizing antibodies against IFN-α2 or IFN-ω is present in patients with severe WNV infection, whereas virtually no asymptomatic WNV-infected subjects have such antibodies (odds ratio 24 [95% confidence interval: 3.0 − 192.5; P = 0.003]). Overall, our experiments establish that blockade of type I IFN signaling extends WNV tropism to enterocytes, which correlates with increased gut and BBB permeability, and more severe disease." @default.
• W4387004224 created "2023-09-26" @default.
• W4387004224 creator A5000384925 @default.
• W4387004224 creator A5029630389 @default.
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• W4387004224 creator A5092932929 @default.
• W4387004224 date "2023-09-25" @default.
• W4387004224 modified "2023-10-17" @default.
• W4387004224 title "Blockade of interferon signaling decreases gut barrier integrity and promotes severe West Nile virus disease" @default.
• W4387004224 cites W1483063718 @default.
• W4387004224 cites W1590810109 @default.
• W4387004224 cites W1841904820 @default.
• W4387004224 cites W1965157206 @default.
• W4387004224 cites W1980840323 @default.
• W4387004224 cites W1981961571 @default.
• W4387004224 cites W1987576327 @default.
• W4387004224 cites W2005549185 @default.
• W4387004224 cites W2011910303 @default.
• W4387004224 cites W2012029948 @default.
• W4387004224 cites W2014246321 @default.
• W4387004224 cites W2014379970 @default.
• W4387004224 cites W2017680126 @default.
• W4387004224 cites W2025471246 @default.
• W4387004224 cites W2034317719 @default.
• W4387004224 cites W2034394095 @default.
• W4387004224 cites W2035509260 @default.
• W4387004224 cites W2037484801 @default.
• W4387004224 cites W2038768395 @default.
• W4387004224 cites W2042094306 @default.
• W4387004224 cites W2044965017 @default.
• W4387004224 cites W2051576743 @default.
• W4387004224 cites W2055972388 @default.
• W4387004224 cites W2067668336 @default.
• W4387004224 cites W2068871282 @default.
• W4387004224 cites W2078811876 @default.
• W4387004224 cites W2079357798 @default.
• W4387004224 cites W2085832434 @default.
• W4387004224 cites W2086763198 @default.
• W4387004224 cites W2092946093 @default.
• W4387004224 cites W2095048886 @default.
• W4387004224 cites W2100155537 @default.
• W4387004224 cites W2110672706 @default.
• W4387004224 cites W2117415703 @default.
• W4387004224 cites W2121525530 @default.
• W4387004224 cites W2125137678 @default.
• W4387004224 cites W2126004312 @default.
• W4387004224 cites W2132214317 @default.
• W4387004224 cites W2132771789 @default.
• W4387004224 cites W2132925416 @default.
• W4387004224 cites W2134248888 @default.
• W4387004224 cites W2138778124 @default.
• W4387004224 cites W2140191892 @default.
• W4387004224 cites W2140326543 @default.
• W4387004224 cites W2147100664 @default.
• W4387004224 cites W2150651447 @default.
• W4387004224 cites W2155589041 @default.
• W4387004224 cites W2159039576 @default.
• W4387004224 cites W2166999328 @default.
• W4387004224 cites W2244784552 @default.
• W4387004224 cites W2471701648 @default.
• W4387004224 cites W2526238900 @default.
• W4387004224 cites W2581120849 @default.
• W4387004224 cites W2752640523 @default.
• W4387004224 cites W2793065417 @default.
• W4387004224 cites W2794010390 @default.
• W4387004224 cites W2794906373 @default.
• W4387004224 cites W2795362564 @default.
• W4387004224 cites W2894969280 @default.
• W4387004224 cites W2946372752 @default.
• W4387004224 cites W2959449984 @default.
• W4387004224 cites W2966476674 @default.
• W4387004224 cites W3082264962 @default.
• W4387004224 cites W3082866225 @default.
• W4387004224 cites W3083833259 @default.
• W4387004224 cites W3084720999 @default.
• W4387004224 cites W3087862874 @default.
• W4387004224 cites W3088256443 @default.
• W4387004224 cites W3111897458 @default.
• W4387004224 cites W3127394181 @default.
• W4387004224 cites W3132635136 @default.
• W4387004224 cites W3157555069 @default.
• W4387004224 cites W3166437541 @default.
• W4387004224 cites W3170100335 @default.
• W4387004224 cites W3195130348 @default.
• W4387004224 cites W3196760175 @default.
• W4387004224 cites W4210686869 @default.
• W4387004224 cites W4213458344 @default.
• W4387004224 cites W4220666805 @default.
• W4387004224 cites W4237675909 @default.
• W4387004224 cites W4238134954 @default.
• W4387004224 cites W4239341883 @default.
• W4387004224 cites W4280525750 @default.
• W4387004224 cites W4282826652 @default.
• W4387004224 cites W4292240525 @default.
• W4387004224 cites W4292960120 @default.
• W4387004224 cites W4296029797 @default.

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