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• W4387006543 abstract "I read with interest the article by Weng et al.,1 titled “Relationship between sarcopenic obesity and cognitive function in patients with mild to moderate Alzheimer's disease,” published in the journal Psychogeriatrics. The study offers valuable insights into the correlation between sarcopenic obesity (SO) and cognitive function in Alzheimer's disease (AD) patients. The research elegantly demonstrates that sarcopenia and SO were independent risk factors for AD.1 These findings echo previous work, such as that of Demura et al., which showed hypoperfusion in key hubs of the central autonomic network to be implicated in the emergence of sarcopenia in older adults with AD.2 However, one aspect that warrants further exploration is the gender-specific impact of SO and sarcopenia on cognitive decline. Demura et al.2 pointed out that sarcopenia and decline in appendicular skeletal muscle mass index (ASMI) were associated with hypoperfusion in different cortical hubs between men and women. This could have potential implications for personalised treatment plans tailored to the patient's gender. Liu et al. also demonstrated that muscle strength was strongly correlated with cognitive function and medial temporal lobe atrophy.3 This complements the study by Weng et al. by emphasising the importance of muscle strength, in addition to SO and sarcopenia, as a crucial factor affecting cognitive function in AD patients. A comprehensive approach considering all these factors might provide a more nuanced understanding of the disease progression and management. Moreover, the concept of cognitive frailty, as discussed by Ruan et al., could further enlighten our understanding of the relationship between SO and cognitive decline in AD patients.4 This is especially relevant when considering emerging biomarkers that could improve early detection and intervention strategies. In conclusion, the study by Weng et al. is a valuable contribution to the growing body of literature on the complex relationship between sarcopenic obesity and AD. Further studies could benefit from an integrative approach that considers gender-specific differences, muscle strength, and emerging biomarkers for cognitive frailty to provide a holistic view of the disease. Thank you for your attention to these reflections, and I look forward to further advancements in this intriguing area of research. Sincerely, Lien-Chung Wei. The author declares no conflicts of interest." @default.
• W4387006543 created "2023-09-26" @default.
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• W4387006543 date "2023-09-25" @default.
• W4387006543 modified "2023-09-27" @default.
• W4387006543 title "Response to “Relationship between sarcopenic obesity and cognitive function in patients with mild to moderate <scp>Alzheimer's</scp> disease”" @default.
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• W4387006543 doi "https://doi.org/10.1111/psyg.13027" @default.
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• W4387006543 hasPublicationYear "2023" @default.
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