FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387008045> ?p ?o ?g. }

• W4387008045 endingPage "779" @default.
• W4387008045 startingPage "771" @default.
• W4387008045 abstract "Disrupting mitochondrial superoxide dismutase (SOD) causes neonatal lethality in mice and death of flies within 24 h after eclosion. Deletion of mitochondrial sod genes in C. elegans impairs fertility as well, but surprisingly is not detrimental to survival of progeny generated. The comparison of metabolic pathways among mouse, flies and nematodes reveals that mice and flies lack the glyoxylate shunt, a shortcut crossing the tricarboxylic acid (TCA) cycle. Here we show that ICL-1, the sole protein that catalyzes the glyoxylate shunt, is critical for protection against embryonic lethality resulting from elevated levels of mitochondrial superoxide. In exploring the mechanism by which ICL-1 protects against ROS-mediated embryonic lethality, we find that ICL-1 is required for the efficient activation of mitochondrial unfolded protein response (UPRmt) and that ATFS-1, a key UPRmt transcription factor and an activator of icl-1 gene expression, is essential to limit embryonic/neonatal lethality in animals lacking mitochondrial SOD. In sum, we identify a biochemical pathway that highlights a molecular strategy for combating toxic mitochondrial superoxide consequences in cells." @default.
• W4387008045 created "2023-09-26" @default.
• W4387008045 creator A5040422300 @default.
• W4387008045 creator A5047648680 @default.
• W4387008045 creator A5052887941 @default.
• W4387008045 creator A5053985419 @default.
• W4387008045 creator A5079841276 @default.
• W4387008045 date "2023-11-01" @default.
• W4387008045 modified "2023-10-08" @default.
• W4387008045 title "The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response" @default.
• W4387008045 cites W1861035294 @default.
• W4387008045 cites W1911972076 @default.
• W4387008045 cites W1974522038 @default.
• W4387008045 cites W1976654687 @default.
• W4387008045 cites W1977943199 @default.
• W4387008045 cites W1980699148 @default.
• W4387008045 cites W1981595048 @default.
• W4387008045 cites W1989323843 @default.
• W4387008045 cites W2007389227 @default.
• W4387008045 cites W2013168115 @default.
• W4387008045 cites W2026758549 @default.
• W4387008045 cites W2042138106 @default.
• W4387008045 cites W2049220511 @default.
• W4387008045 cites W2056015556 @default.
• W4387008045 cites W2058821788 @default.
• W4387008045 cites W2059595592 @default.
• W4387008045 cites W2074783650 @default.
• W4387008045 cites W2088949307 @default.
• W4387008045 cites W2094655287 @default.
• W4387008045 cites W2107277218 @default.
• W4387008045 cites W2108903857 @default.
• W4387008045 cites W2130973560 @default.
• W4387008045 cites W2159810756 @default.
• W4387008045 cites W2166146113 @default.
• W4387008045 cites W2337621927 @default.
• W4387008045 cites W2344482801 @default.
• W4387008045 cites W2520866824 @default.
• W4387008045 cites W2602566183 @default.
• W4387008045 cites W2606022362 @default.
• W4387008045 cites W2765389667 @default.
• W4387008045 cites W2765579241 @default.
• W4387008045 cites W2770372563 @default.
• W4387008045 cites W2789336604 @default.
• W4387008045 cites W2793516758 @default.
• W4387008045 cites W2793897503 @default.
• W4387008045 cites W2892337114 @default.
• W4387008045 cites W2904192199 @default.
• W4387008045 cites W2908707862 @default.
• W4387008045 cites W2984558615 @default.
• W4387008045 cites W3012803745 @default.
• W4387008045 cites W3030420142 @default.
• W4387008045 doi "https://doi.org/10.1016/j.freeradbiomed.2023.09.029" @default.
• W4387008045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37758122" @default.
• W4387008045 hasPublicationYear "2023" @default.
• W4387008045 type Work @default.
• W4387008045 citedByCount "0" @default.
• W4387008045 crossrefType "journal-article" @default.
• W4387008045 hasAuthorship W4387008045A5040422300 @default.
• W4387008045 hasAuthorship W4387008045A5047648680 @default.
• W4387008045 hasAuthorship W4387008045A5052887941 @default.
• W4387008045 hasAuthorship W4387008045A5053985419 @default.
• W4387008045 hasAuthorship W4387008045A5079841276 @default.
• W4387008045 hasConcept C104317684 @default.
• W4387008045 hasConcept C111491248 @default.
• W4387008045 hasConcept C163950672 @default.
• W4387008045 hasConcept C165135838 @default.
• W4387008045 hasConcept C165267168 @default.
• W4387008045 hasConcept C181199279 @default.
• W4387008045 hasConcept C200886947 @default.
• W4387008045 hasConcept C20379349 @default.
• W4387008045 hasConcept C24586158 @default.
• W4387008045 hasConcept C2775838275 @default.
• W4387008045 hasConcept C2776108821 @default.
• W4387008045 hasConcept C2776151105 @default.
• W4387008045 hasConcept C2780795997 @default.
• W4387008045 hasConcept C28859421 @default.
• W4387008045 hasConcept C54355233 @default.
• W4387008045 hasConcept C55493867 @default.
• W4387008045 hasConcept C62231903 @default.
• W4387008045 hasConcept C86803240 @default.
• W4387008045 hasConcept C95444343 @default.
• W4387008045 hasConceptScore W4387008045C104317684 @default.
• W4387008045 hasConceptScore W4387008045C111491248 @default.
• W4387008045 hasConceptScore W4387008045C163950672 @default.
• W4387008045 hasConceptScore W4387008045C165135838 @default.
• W4387008045 hasConceptScore W4387008045C165267168 @default.
• W4387008045 hasConceptScore W4387008045C181199279 @default.
• W4387008045 hasConceptScore W4387008045C200886947 @default.
• W4387008045 hasConceptScore W4387008045C20379349 @default.
• W4387008045 hasConceptScore W4387008045C24586158 @default.
• W4387008045 hasConceptScore W4387008045C2775838275 @default.
• W4387008045 hasConceptScore W4387008045C2776108821 @default.
• W4387008045 hasConceptScore W4387008045C2776151105 @default.
• W4387008045 hasConceptScore W4387008045C2780795997 @default.
• W4387008045 hasConceptScore W4387008045C28859421 @default.
• W4387008045 hasConceptScore W4387008045C54355233 @default.
• W4387008045 hasConceptScore W4387008045C55493867 @default.
• W4387008045 hasConceptScore W4387008045C62231903 @default.

• next