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- W4387008240 abstract "Targeted protein degradation (TPD) has emerged as the most promising approach for the specific knockdown of disease-associated proteins and is achieved by exploiting the cellular quality control machinery. TPD technologies are highly advantageous in overcoming drug resistance as they degrade the whole target protein. Microtubules play important roles in many cellular processes and are among the oldest and most well-established targets for tumor chemotherapy. However, the development of drug resistance, risk of hypersensitivity reactions, and intolerable toxicities severely restrict the clinical applications of microtubule-targeting agents (MTAs). Microtubule degradation agents (MDgAs) operate via completely different mechanisms compared with traditional MTAs and are capable of overcoming drug resistance. The emergence of MDgAs has expanded the scope of TPD and provided new avenues for the discovery of tubulin-targeted drugs. Herein, we summarized the development of MDgAs, and discussed their degradation mechanisms, mechanisms of action on the binding sites, potential opportunities, and challenges." @default.
- W4387008240 created "2023-09-26" @default.
- W4387008240 creator A5000948146 @default.
- W4387008240 creator A5012541893 @default.
- W4387008240 creator A5021570291 @default.
- W4387008240 creator A5085960809 @default.
- W4387008240 date "2023-09-25" @default.
- W4387008240 modified "2023-10-13" @default.
- W4387008240 title "Recent Progress on Microtubule Degradation Agents" @default.
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