FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387009053> ?p ?o ?g. }

• W4387009053 abstract "Introduction: Acetaminophen poisoning is commonly treated by emergency physicians. First-line therapy is N-acetylcysteine (NAC), traditionally administered intravenously via a US Food and Drug Administration (FDA)-approved three-bag protocol in which each bag has a unique concentration and infusion duration. Recently, simplified, off-label two-bag NAC infusion protocols have become more common. The purpose of this review is to summarize the effectiveness and safety of two-bag NAC.Methods: We undertook a comprehensive search of PubMed, EMBASE, and MEDLINE from inception to December 13, 2022, for articles describing human acetaminophen poisonings treated with two-bag NAC, defined as any regimen involving two discrete infusions in two separate bags. Outcomes included effectiveness (measured by incidence of liver injury); incidence of non-allergic anaphylactoid reactions (NAAR); gastrointestinal, cutaneous, and systemic reactions; treatments for NAARs; incidence of NAC-related medication errors; and delays or interruptions in NAC administration.Results: Twelve articles met final inclusion, 10 of which compared two-bag NAC to the three-bag regimen. Nine articles evaluated the two-bag/20-hour regimen, a simplified version of the FDA-approved three-bag regimen in which the traditional first and second bags are combined into a single four-hour infusion. Nine articles assessed comparative effectiveness of two-bag NAC in terms of liver injury, most commonly assessed for by incidence of hepatotoxicity (aspartate aminotransferase or alanine aminotransferase >1,000 international units per liter). No difference in liver injury was observed between two-bag and three-bag regimens. Of nine articles comparing incidence of NAARs, eight demonstrated statistically fewer NAARs with two-bag regimens, and one showed no difference. In seven articles evaluating treatment for NAARs (antihistamines, corticosteroids, epinephrine), all showed that patients received fewer medications for NAARs with two-bag NAC. Three articles evaluated NAC-related medication errors; two demonstrated no difference, while one study evaluating only children showed fewer errors with two-bag NAC. Two studies evaluated delays and/or interruptions in NAC infusions; both favored two-bag NAC.Conclusion: For patients with acetaminophen poisoning, two-bag NAC regimens appear to have similar outcomes to the traditional three-bag regimen in terms of liver injury. Two-bag NAC regimens are associated with fewer adverse events and fewer treatments for those events than the three-bag regimen and fewer interruptions in antidotal therapy." @default.
• W4387009053 created "2023-09-26" @default.
• W4387009053 creator A5003799053 @default.
• W4387009053 creator A5042237792 @default.
• W4387009053 creator A5054889999 @default.
• W4387009053 creator A5062320586 @default.
• W4387009053 creator A5084237031 @default.
• W4387009053 creator A5084407314 @default.
• W4387009053 creator A5092933912 @default.
• W4387009053 date "2013-02-15" @default.
• W4387009053 modified "2023-09-26" @default.
• W4387009053 title "Is Two Better Than Three? A Systematic Review of Two-bag Intravenous N-acetylcysteine Regimens for Acetaminophen Poisoning" @default.
• W4387009053 doi "https://doi.org/10.5811/westjem.59099" @default.
• W4387009053 hasPublicationYear "2013" @default.
• W4387009053 type Work @default.
• W4387009053 citedByCount "0" @default.
• W4387009053 crossrefType "journal-article" @default.
• W4387009053 hasAuthorship W4387009053A5003799053 @default.
• W4387009053 hasAuthorship W4387009053A5042237792 @default.
• W4387009053 hasAuthorship W4387009053A5054889999 @default.
• W4387009053 hasAuthorship W4387009053A5062320586 @default.
• W4387009053 hasAuthorship W4387009053A5084237031 @default.
• W4387009053 hasAuthorship W4387009053A5084407314 @default.
• W4387009053 hasAuthorship W4387009053A5092933912 @default.
• W4387009053 hasBestOaLocation W43870090531 @default.
• W4387009053 hasConcept C118552586 @default.
• W4387009053 hasConcept C120665830 @default.
• W4387009053 hasConcept C121332964 @default.
• W4387009053 hasConcept C126322002 @default.
• W4387009053 hasConcept C141071460 @default.
• W4387009053 hasConcept C185592680 @default.
• W4387009053 hasConcept C2776637226 @default.
• W4387009053 hasConcept C2777847592 @default.
• W4387009053 hasConcept C2778004101 @default.
• W4387009053 hasConcept C2778722691 @default.
• W4387009053 hasConcept C2780724011 @default.
• W4387009053 hasConcept C2781413609 @default.
• W4387009053 hasConcept C42219234 @default.
• W4387009053 hasConcept C55493867 @default.
• W4387009053 hasConcept C61511704 @default.
• W4387009053 hasConcept C71924100 @default.
• W4387009053 hasConceptScore W4387009053C118552586 @default.
• W4387009053 hasConceptScore W4387009053C120665830 @default.
• W4387009053 hasConceptScore W4387009053C121332964 @default.
• W4387009053 hasConceptScore W4387009053C126322002 @default.
• W4387009053 hasConceptScore W4387009053C141071460 @default.
• W4387009053 hasConceptScore W4387009053C185592680 @default.
• W4387009053 hasConceptScore W4387009053C2776637226 @default.
• W4387009053 hasConceptScore W4387009053C2777847592 @default.
• W4387009053 hasConceptScore W4387009053C2778004101 @default.
• W4387009053 hasConceptScore W4387009053C2778722691 @default.
• W4387009053 hasConceptScore W4387009053C2780724011 @default.
• W4387009053 hasConceptScore W4387009053C2781413609 @default.
• W4387009053 hasConceptScore W4387009053C42219234 @default.
• W4387009053 hasConceptScore W4387009053C55493867 @default.
• W4387009053 hasConceptScore W4387009053C61511704 @default.
• W4387009053 hasConceptScore W4387009053C71924100 @default.
• W4387009053 hasIssue "0" @default.
• W4387009053 hasLocation W43870090531 @default.
• W4387009053 hasOpenAccess W4387009053 @default.
• W4387009053 hasPrimaryLocation W43870090531 @default.
• W4387009053 hasRelatedWork W1988371333 @default.
• W4387009053 hasRelatedWork W2103959272 @default.
• W4387009053 hasRelatedWork W2275779843 @default.
• W4387009053 hasRelatedWork W2546014627 @default.
• W4387009053 hasRelatedWork W2570273750 @default.
• W4387009053 hasRelatedWork W3118107215 @default.
• W4387009053 hasRelatedWork W3211872568 @default.
• W4387009053 hasRelatedWork W4206630757 @default.
• W4387009053 hasRelatedWork W4240971076 @default.
• W4387009053 hasRelatedWork W4295437235 @default.
• W4387009053 hasVolume "0" @default.
• W4387009053 isParatext "false" @default.
• W4387009053 isRetracted "false" @default.
• W4387009053 workType "article" @default.