Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387011132> ?p ?o ?g. }
- W4387011132 abstract "Summary Abnormal spindle-like, microcephaly-associated ( ASPM ) is the most commonly mutated gene in primary microcephaly (MCPH), characterized by reduced brain size and intellectual deficiency. The mechanisms underlying MCPH have remained unclear, as ASPM disruption leads to distinct phenotypes depending on the species studied. Here, we studied the impact of ASPM pathogenic mutations on human corticogenesis in organoid models. We found that at earliest stages of neurogenesis, ASPM mutant cortical progenitors, located at the apical surface of the neuroepithelium, display transient mitotic spindle randomization. The mutant progenitors then delaminate basally to adopt precociously the characteristics of outer radial glia cells (oRGC), a population of progenitors selectively amplified in human corticogenesis. Subsequently, cortical progenitors are depleted through decreased amplification and increased apoptosis. Thus, ASPM regulates the timely generation of oRGC by controlling mitotic spindle orientation, shedding light on how species-specific features of neurogenesis may confer vulnerability to neurodevelopmental diseases." @default.
- W4387011132 created "2023-09-26" @default.
- W4387011132 creator A5000323728 @default.
- W4387011132 creator A5009999392 @default.
- W4387011132 creator A5015888784 @default.
- W4387011132 creator A5022431389 @default.
- W4387011132 creator A5023843176 @default.
- W4387011132 creator A5026477272 @default.
- W4387011132 creator A5033282224 @default.
- W4387011132 creator A5034471051 @default.
- W4387011132 creator A5047726602 @default.
- W4387011132 creator A5057850843 @default.
- W4387011132 creator A5064977245 @default.
- W4387011132 creator A5069874308 @default.
- W4387011132 creator A5071489814 @default.
- W4387011132 creator A5076948411 @default.
- W4387011132 creator A5089852959 @default.
- W4387011132 creator A5091009184 @default.
- W4387011132 creator A5092639086 @default.
- W4387011132 creator A5092934245 @default.
- W4387011132 date "2023-09-25" @default.
- W4387011132 modified "2023-10-14" @default.
- W4387011132 title "The microcephaly gene ASPM is required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientation" @default.
- W4387011132 cites W1966686696 @default.
- W4387011132 cites W1967536597 @default.
- W4387011132 cites W1968342623 @default.
- W4387011132 cites W1969841831 @default.
- W4387011132 cites W1975087758 @default.
- W4387011132 cites W1981836772 @default.
- W4387011132 cites W1982953805 @default.
- W4387011132 cites W1988976106 @default.
- W4387011132 cites W1997311727 @default.
- W4387011132 cites W1999511738 @default.
- W4387011132 cites W2000345419 @default.
- W4387011132 cites W2003067279 @default.
- W4387011132 cites W2005889749 @default.
- W4387011132 cites W2008370035 @default.
- W4387011132 cites W2018286352 @default.
- W4387011132 cites W2028489893 @default.
- W4387011132 cites W2029245198 @default.
- W4387011132 cites W2032850366 @default.
- W4387011132 cites W2036162361 @default.
- W4387011132 cites W2044952675 @default.
- W4387011132 cites W2045387875 @default.
- W4387011132 cites W2051785391 @default.
- W4387011132 cites W2055803972 @default.
- W4387011132 cites W2057193274 @default.
- W4387011132 cites W2060299616 @default.
- W4387011132 cites W2067874442 @default.
- W4387011132 cites W2069892107 @default.
- W4387011132 cites W2072710787 @default.
- W4387011132 cites W2075956100 @default.
- W4387011132 cites W2084168227 @default.
- W4387011132 cites W2085420625 @default.
- W4387011132 cites W2087786585 @default.
- W4387011132 cites W2089651828 @default.
- W4387011132 cites W2090162743 @default.
- W4387011132 cites W2096960876 @default.
- W4387011132 cites W2103767482 @default.
- W4387011132 cites W2104254530 @default.
- W4387011132 cites W2109598153 @default.
- W4387011132 cites W2111145604 @default.
- W4387011132 cites W2112855374 @default.
- W4387011132 cites W2123903329 @default.
- W4387011132 cites W2127220436 @default.
- W4387011132 cites W2129016496 @default.
- W4387011132 cites W2136662452 @default.
- W4387011132 cites W2139016305 @default.
- W4387011132 cites W2141251844 @default.
- W4387011132 cites W2145943053 @default.
- W4387011132 cites W2150197150 @default.
- W4387011132 cites W2150553603 @default.
- W4387011132 cites W2153292012 @default.
- W4387011132 cites W2153676981 @default.
- W4387011132 cites W2159884201 @default.
- W4387011132 cites W2166643977 @default.
- W4387011132 cites W2169786878 @default.
- W4387011132 cites W2172266256 @default.
- W4387011132 cites W2188223075 @default.
- W4387011132 cites W2252568502 @default.
- W4387011132 cites W2290993632 @default.
- W4387011132 cites W2418103812 @default.
- W4387011132 cites W2521106965 @default.
- W4387011132 cites W2543622711 @default.
- W4387011132 cites W2735004254 @default.
- W4387011132 cites W2766567783 @default.
- W4387011132 cites W2774193101 @default.
- W4387011132 cites W2796982507 @default.
- W4387011132 cites W2800392236 @default.
- W4387011132 cites W2935521291 @default.
- W4387011132 cites W2944848806 @default.
- W4387011132 cites W2950534331 @default.
- W4387011132 cites W2980995354 @default.
- W4387011132 cites W2984472267 @default.
- W4387011132 cites W2994844348 @default.
- W4387011132 cites W2999189773 @default.
- W4387011132 cites W3004345103 @default.
- W4387011132 cites W3115464675 @default.
- W4387011132 cites W3159523558 @default.
- W4387011132 cites W3201171265 @default.