Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387012211> ?p ?o ?g. }
- W4387012211 abstract "Cell proliferation is a ubiquitous process required for organismal development and homeostasis. However, individuals with partial loss-of-function variants in DNA replicative helicase components often present with immunodeficiency due to specific loss of natural killer (NK) cells. Such lineage-specific disease phenotypes raise questions on how the proliferation is regulated in cell type-specific manner. We aimed to understand NK cell-specific proliferative dynamics and vulnerability to impaired helicase function using iPSCs from individuals with NK cell deficiency (NKD) due to hereditary compound heterozygous GINS4 variants. We observed and characterized heterogeneous cell populations that arise during the iPSC differentiation along with NK cells. While overall cell proliferation decreased with differentiation, early NK cell precursors showed a short burst of cell proliferation. GINS4 deficiency induced replication stress in these early NK cell precursors, which are poised for apoptosis, and ultimately recapitulate the NKD phenotype." @default.
- W4387012211 created "2023-09-26" @default.
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- W4387012211 date "2023-09-25" @default.
- W4387012211 modified "2023-10-14" @default.
- W4387012211 title "iPSC-based modeling of helicase deficiency reveals impaired cell proliferation and increased apoptosis after NK cell lineage commitment" @default.
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- W4387012211 doi "https://doi.org/10.1101/2023.09.25.559149" @default.
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- W4387012211 hasPublicationYear "2023" @default.
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