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- W4387013674 abstract "Acetylcholine is released in visual cortex by axonal projections from the basal forebrain. The signals conveyed by these projections and their computational significance are still unclear. Using two-photon calcium imaging in behaving mice, we show that basal forebrain cholinergic axons in the mouse visual cortex provide a binary locomotion state signal. In these axons, we found no evidence of responses to visual stimuli or visuomotor prediction errors. While optogenetic activation of cholinergic axons in visual cortex in isolation did not drive local neuronal activity, when paired with visuomotor stimuli, it resulted in layer-specific increases of neuronal activity. Responses in layer 5 excitatory neurons to both top-down and bottom-up inputs were increased in amplitude and decreased in latency, whereas those in layer 2/3 neurons remained unchanged. Using opto- and chemogenetic manipulations of cholinergic activity, we found acetylcholine to underlie the locomotion-associated decorrelation of activity between excitatory neurons in both layer 2/3 and layer 5. Our results suggest that acetylcholine augments the responsiveness of layer 5 neurons to inputs from outside of the local network, enabling faster switching between internal representations during locomotion." @default.
- W4387013674 created "2023-09-26" @default.
- W4387013674 date "2023-09-25" @default.
- W4387013674 modified "2023-10-14" @default.
- W4387013674 title "Reviewer #1 (Public Review): Cholinergic input to mouse visual cortex signals a movement state and acutely enhances layer 5 responsiveness" @default.
- W4387013674 doi "https://doi.org/10.7554/elife.89986.1.sa1" @default.
- W4387013674 hasPublicationYear "2023" @default.
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