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- W4387013756 endingPage "e202302122" @default.
- W4387013756 startingPage "e202302122" @default.
- W4387013756 abstract "Hundreds of mitochondrial proteins with N-terminal presequences are translocated across the outer and inner mitochondrial membranes via the TOM and TIM23 complexes, respectively. How translocation of proteins across two mitochondrial membranes is coordinated is largely unknown. Here, we show that the two domains of Tim50 in the intermembrane space, named core and PBD, both have essential roles in this process. Building upon the surprising observation that the two domains of Tim50 can complement each other in trans, we establish that the core domain contains the main presequence-binding site and serves as the main recruitment point to the TIM23 complex. On the other hand, the PBD plays, directly or indirectly, a critical role in cooperation of the TOM and TIM23 complexes and supports the receptor function of Tim50. Thus, the two domains of Tim50 both have essential but distinct roles and together coordinate translocation of proteins across two mitochondrial membranes." @default.
- W4387013756 created "2023-09-26" @default.
- W4387013756 creator A5002985017 @default.
- W4387013756 creator A5004043557 @default.
- W4387013756 creator A5006113148 @default.
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- W4387013756 creator A5040849032 @default.
- W4387013756 creator A5041072537 @default.
- W4387013756 creator A5059038419 @default.
- W4387013756 creator A5087959237 @default.
- W4387013756 date "2023-09-25" @default.
- W4387013756 modified "2023-09-29" @default.
- W4387013756 title "Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes" @default.
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- W4387013756 doi "https://doi.org/10.26508/lsa.202302122" @default.
- W4387013756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37748811" @default.