Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387013875> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W4387013875 abstract "Dopamine system dysfunction is commonly implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive symptoms remain unresponsive to such pharmacological treatments and novel research paradigms investigating the circuit substrates underlying cognitive deficits are critically needed. The frontal cortex and its dopaminergic input from the midbrain are implicated in cognitive functions and undergo maturational changes during adolescence. Here, we used mice carrying mutations in the Arc or DISC1 genes to model mesofrontal dopamine circuit deficiencies and test circuit-based neurostimulation strategies to restore cognitive functions. We found that in a memory-guided spatial navigation task, frontal cortical neurons were activated coordinately at the decision-making point in wild-type but not Arc mutant mice. Chemogenetic stimulation of midbrain dopamine neurons or optogenetic stimulation of frontal cortical dopamine axons in a limited adolescent period consistently reversed genetic defects in mesofrontal innervation, task-coordinated neuronal activity, and memory-guided decision-making at adulthood. Furthermore, adolescent stimulation of dopamine neurons also reversed the same cognitive deficits in DISC1 mutant mice. Our findings reveal common mesofrontal circuit alterations underlying the cognitive deficits caused by two different genes and demonstrate the feasibility of adolescent neurostimulation to reverse these circuit and behavioral deficits. These results may suggest developmental windows and circuit targets for treating cognitive deficits in neurodevelopmental disorders." @default.
- W4387013875 created "2023-09-26" @default.
- W4387013875 creator A5042684804 @default.
- W4387013875 date "2023-09-25" @default.
- W4387013875 modified "2023-09-26" @default.
- W4387013875 title "eLife assessment: Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function" @default.
- W4387013875 doi "https://doi.org/10.7554/elife.87414.2.sa0" @default.
- W4387013875 hasPublicationYear "2023" @default.
- W4387013875 type Work @default.
- W4387013875 citedByCount "0" @default.
- W4387013875 crossrefType "peer-review" @default.
- W4387013875 hasAuthorship W4387013875A5042684804 @default.
- W4387013875 hasBestOaLocation W43870138751 @default.
- W4387013875 hasConcept C126322002 @default.
- W4387013875 hasConcept C137183658 @default.
- W4387013875 hasConcept C15744967 @default.
- W4387013875 hasConcept C169760540 @default.
- W4387013875 hasConcept C169900460 @default.
- W4387013875 hasConcept C24998067 @default.
- W4387013875 hasConcept C2776443511 @default.
- W4387013875 hasConcept C2778542668 @default.
- W4387013875 hasConcept C2779134260 @default.
- W4387013875 hasConcept C2779734285 @default.
- W4387013875 hasConcept C50738837 @default.
- W4387013875 hasConcept C513476851 @default.
- W4387013875 hasConcept C71924100 @default.
- W4387013875 hasConceptScore W4387013875C126322002 @default.
- W4387013875 hasConceptScore W4387013875C137183658 @default.
- W4387013875 hasConceptScore W4387013875C15744967 @default.
- W4387013875 hasConceptScore W4387013875C169760540 @default.
- W4387013875 hasConceptScore W4387013875C169900460 @default.
- W4387013875 hasConceptScore W4387013875C24998067 @default.
- W4387013875 hasConceptScore W4387013875C2776443511 @default.
- W4387013875 hasConceptScore W4387013875C2778542668 @default.
- W4387013875 hasConceptScore W4387013875C2779134260 @default.
- W4387013875 hasConceptScore W4387013875C2779734285 @default.
- W4387013875 hasConceptScore W4387013875C50738837 @default.
- W4387013875 hasConceptScore W4387013875C513476851 @default.
- W4387013875 hasConceptScore W4387013875C71924100 @default.
- W4387013875 hasLocation W43870138751 @default.
- W4387013875 hasOpenAccess W4387013875 @default.
- W4387013875 hasPrimaryLocation W43870138751 @default.
- W4387013875 hasRelatedWork W2023916971 @default.
- W4387013875 hasRelatedWork W2072920560 @default.
- W4387013875 hasRelatedWork W2192170494 @default.
- W4387013875 hasRelatedWork W2418592407 @default.
- W4387013875 hasRelatedWork W2888802596 @default.
- W4387013875 hasRelatedWork W3024275906 @default.
- W4387013875 hasRelatedWork W3205902602 @default.
- W4387013875 hasRelatedWork W4205635425 @default.
- W4387013875 hasRelatedWork W4293586768 @default.
- W4387013875 hasRelatedWork W4362733936 @default.
- W4387013875 isParatext "false" @default.
- W4387013875 isRetracted "false" @default.
- W4387013875 workType "peer-review" @default.