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- W4387014039 abstract "Background: The majority of skin infections associated with non-healing chronic wounds are thought to be biofilm-related and polymicrobial, but comparative studies that evaluate commercially available dressings against polymicrobial biofilms are lacking. In this study, a porcine ex vivo skin wound polymicrobial biofilm model incorporating washing and soft debridement steps were used to assess the efficacy of 6 commonly used antimicrobial dressings to reduce mature biofilms consisting of multidrug- resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and Candida albicans. These included cadexomer iodine gel, octenidine HCl gel, calcium alginate/carboxymethylcellulose/ionic silver (alginate/CMC/Ag), polyurethane foam/silver sulfate, hypochlorous acid-soaked gauze (HOCl), and polyhexamethylene biguanide gauze (n=9 per treatment). Gram, Hucker-Twort staining of paraffin sections revealed polymicrobial communities in 3-day established biofilms. All dressings, including water- soaked gauze (control dressing), reduced biofilm thickness by 41%-61% compared to untreated biofilms after 24h of treatment when applied to biofilms 2 days after inoculation. Alginate/CMC/Ag, cadexomer iodine, and HOCl performed the best overall, reducing biofilm thickness by 23.5% (p=0.04), 9.9% (p=0.04), and 17.9% (p=0.29) vs. control dressing, respectively. Qualitative observations found that these 3 dressings also appeared to harbor the fewest organisms. These findings suggest that widely used antimicrobial wound dressings vary in their ability to reduce mature biofilm, and differences occur even between silver dressings. Although no dressing was able to eradicate biofilm after 24h of treatment in this ex vivo model, alginate/CMC/Ag, cadexomer iodine, and HOCl demonstrate promising antibiofilm activity. Further investigation in vivo in clinical studies is warranted as well as efforts to determine the optimum duration of treatment." @default.
- W4387014039 created "2023-09-26" @default.
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- W4387014039 date "2023-09-01" @default.
- W4387014039 modified "2023-10-01" @default.
- W4387014039 title "42118 Antibiofilm Activity of Antimicrobial Dressings in a Porcine Ex Vivo Skin Wound Polymicrobial Biofilm Model" @default.
- W4387014039 doi "https://doi.org/10.1016/j.jaad.2023.07.488" @default.
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