Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387014321> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- W4387014321 endingPage "AB92" @default.
- W4387014321 startingPage "AB92" @default.
- W4387014321 abstract "Lichen sclerosus (LS) is a chronic, inflammatory process affecting predominantly anogenital skin, with extragenital involvement in 6-20% of patients.1 LS manifests as hypopigmented to depigmented, erythematous, atrophic patches and plaques, associated with itch, as well as pain, dyspareunia, and dysuria when involving the genitalia. Chronic anogenital involvement can lead to scarring and carries an increased risk of skin cancer.2 The mainstay of therapy is currently topical immunosuppression.3 As the etiology of lichen sclerosus remains unknown and refractory cases can be debilitating for patients, systemic treatment modalities such as immunosuppressants, antibiotics, retinoids, and biologics have been utilized, without current guidelines on use of systemic therapy for LS. Herein, we performed a systematic review to evaluate systemic therapies for LS. A search using PubMed, OVID, Scopus, and Web of Science yielded 781 studies. After application of inclusion and exclusion criteria, 81 studies consisting of 359 patients were included for data extraction. 65.5% had genital LS; 7.5% had extra-genital LS; and 27% had both. Common systemic modalities included: oral vitamin A derivatives (45%), methotrexate (14%), prednisone (9%), and hydroxychloroquine (7%). Overall, 83% of cases reported improvement following systematic treatment, 15% reported no improvement, and 2% did not report outcomes." @default.
- W4387014321 created "2023-09-26" @default.
- W4387014321 creator A5009624805 @default.
- W4387014321 creator A5089994305 @default.
- W4387014321 creator A5092934951 @default.
- W4387014321 date "2023-09-01" @default.
- W4387014321 modified "2023-09-26" @default.
- W4387014321 title "43604 Systemic Therapies for Lichen Sclerosus: A Systematic Review" @default.
- W4387014321 doi "https://doi.org/10.1016/j.jaad.2023.07.370" @default.
- W4387014321 hasPublicationYear "2023" @default.
- W4387014321 type Work @default.
- W4387014321 citedByCount "0" @default.
- W4387014321 crossrefType "journal-article" @default.
- W4387014321 hasAuthorship W4387014321A5009624805 @default.
- W4387014321 hasAuthorship W4387014321A5089994305 @default.
- W4387014321 hasAuthorship W4387014321A5092934951 @default.
- W4387014321 hasConcept C126322002 @default.
- W4387014321 hasConcept C137627325 @default.
- W4387014321 hasConcept C16005928 @default.
- W4387014321 hasConcept C2776552008 @default.
- W4387014321 hasConcept C71924100 @default.
- W4387014321 hasConceptScore W4387014321C126322002 @default.
- W4387014321 hasConceptScore W4387014321C137627325 @default.
- W4387014321 hasConceptScore W4387014321C16005928 @default.
- W4387014321 hasConceptScore W4387014321C2776552008 @default.
- W4387014321 hasConceptScore W4387014321C71924100 @default.
- W4387014321 hasIssue "3" @default.
- W4387014321 hasLocation W43870143211 @default.
- W4387014321 hasOpenAccess W4387014321 @default.
- W4387014321 hasPrimaryLocation W43870143211 @default.
- W4387014321 hasRelatedWork W1831952958 @default.
- W4387014321 hasRelatedWork W2049142096 @default.
- W4387014321 hasRelatedWork W2081582017 @default.
- W4387014321 hasRelatedWork W2329339957 @default.
- W4387014321 hasRelatedWork W2412965123 @default.
- W4387014321 hasRelatedWork W2465854091 @default.
- W4387014321 hasRelatedWork W2783931507 @default.
- W4387014321 hasRelatedWork W3002986063 @default.
- W4387014321 hasRelatedWork W4243793997 @default.
- W4387014321 hasRelatedWork W4322705554 @default.
- W4387014321 hasVolume "89" @default.
- W4387014321 isParatext "false" @default.
- W4387014321 isRetracted "false" @default.
- W4387014321 workType "article" @default.