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- W4387015280 abstract "<p>Tucatinib alters the internalization dynamics of HER2-targeted antibodies. <b>A,</b> Schematic of pulsed internalization assay with AF488 fluorescently-labeled trastuzumab. <b>B,</b> Images of SK-BR-3 cells in pulsed internalization assays incubated with AF488 fluorescently-labeled trastuzumab and/or treated with tucatinib or neratinib. Inlay images show counterstaining (Hoechst) to signify distribution of cells. <b>C,</b> Magnified images of tucatinib-treated cells in internalization assays, counterstained with lysosomal marker LAMP1. Chloroquine, which inhibits lysosomal function (<a href=#bib49 target=_blank>49</a>), was added to show more intense colocalization when lysosomal degradation is impaired. These results are representative of at least 2 independent experiments.</p>" @default.
- W4387015280 created "2023-09-26" @default.
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- W4387015280 date "2023-09-25" @default.
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- W4387015280 title "FIGURE 3 from HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer" @default.
- W4387015280 doi "https://doi.org/10.1158/2767-9764.24191695" @default.
- W4387015280 hasPublicationYear "2023" @default.
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