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- W4387015777 abstract "Background: Dermatomyositis (DM) is an idiopathic inflammatory myopathy that encompasses skin symptoms, skeletal muscle involvement and a broad spectrum of autoantibodies. It can associate systemic manifestations and neoplasms. Up to 18% of patients lack traditional myopathy which defines a subtype called amyopathic DM (ADM). An 88-year-old woman diagnosed with ADM was monitored for 10 years. Malignancy screening tests were repeatedly negative, and skin lesions resolved with oral azathioprine. 15 years after DM diagnosis, she returned to our clinical setting showing erythematous plaques over the dorsum of the hands, periungual erythema and dystrophic cuticles. The examination also revealed poikiloderma on both hips and erythematous, scaly plaques on the scalp. The blood test showed a significant increase in CA 19.9 and the small ubiquitin-like modifier activating enzyme (SAE-1) antibodies were also positive. A thoracic abdominopelvic scan was performed suggesting primary pancreatic neoplasia with metastatic liver disease. Patients with ADM seem to be at risk for developing internal malignancy. SAE antibodies are only seen in an 8% of patients with DM and they are related to severe cutaneous disease with minimal myopathy. Their association with malignancy is still unknown." @default.
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- W4387015777 date "2023-09-01" @default.
- W4387015777 modified "2023-09-26" @default.
- W4387015777 title "43168 Amyopathic Dermatomyositis: When Malignancy Is Lurking In The Shadows" @default.
- W4387015777 doi "https://doi.org/10.1016/j.jaad.2023.07.474" @default.
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