Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387017130> ?p ?o ?g. }
- W4387017130 abstract "Targeted protein degradation (TPD) involving chimeric molecules has emerged as one of the most promising therapeutic modalities in recent years. Among various reported TPD strategies, proteolysis-targeting chimeras (PROTACs) stand out as a significant breakthrough in small-molecule drug discovery and have garnered the most attention to date. However, PROTACs are mainly capable of depleting intracellular proteins. Given that many important therapeutic targets such as cytokines, growth factors, and numerous receptors are membrane proteins or secreted extracellularly, there is interest in the development of novel strategies to degrade these protein categories. We review advances in this emerging area and provide insights to enhance the development of novel TPDs targeting extracellular proteins." @default.
- W4387017130 created "2023-09-26" @default.
- W4387017130 creator A5021157362 @default.
- W4387017130 creator A5023391698 @default.
- W4387017130 creator A5024901877 @default.
- W4387017130 creator A5087354808 @default.
- W4387017130 date "2023-09-01" @default.
- W4387017130 modified "2023-10-15" @default.
- W4387017130 title "Targeted degradation of extracellular secreted and membrane proteins" @default.
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- W4387017130 doi "https://doi.org/10.1016/j.tips.2023.08.013" @default.
- W4387017130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37758536" @default.