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- W4387018551 abstract "Abstract R-loops are a class of non-canonical nucleic acid structures that typically form during transcription, when the nascent RNA hybridizes with the DNA template strand, leaving the DNA coding strand unpaired. Co-transcriptional R-loops are abundant in nature and biologically relevant. Recent research shows that DNA sequence and topology affect R-loops, and yet it remains unclear how these and other factors drive R-loop formation. In this work, we investigate the link between the secondary structure of the nascent RNA and the probability of R-loop formation. We introduce tree-polynomial representations, a mathematical object that enables accurate and efficient data analysis of RNA secondary structures. With tree-polynomial representations, we establish a strong correlation between the secondary structure of the RNA transcript and the probability of R-loop formation. We identify that branches with short stems separated by multiple bubbles in the RNA secondary structure drive the strong correlation and potentially promote R-loop formation." @default.
- W4387018551 created "2023-09-26" @default.
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- W4387018551 date "2023-09-25" @default.
- W4387018551 modified "2023-09-30" @default.
- W4387018551 title "Analyzing the link between RNA secondary structures and R-loop formation with tree polynomials" @default.
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- W4387018551 doi "https://doi.org/10.1101/2023.09.24.559224" @default.
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