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• W4387020198 abstract "Abstract Purpose: Limited data are available on the relationship of parasympathetic nervous function with the prevalence of prediabetes and diabetes in men and women. We conducted a cross-sectional study to investigate the relationship between diving reflex - markers of parasympathetic nervous function - with the prevalence of prediabetes and diabetes among men and women in WASEDA'S Health Study. Methods: Participants were 199 men and 75 women who completed a medical examination, maximal exercise test, and diving reflex test. The participants were divided into tertiles based on the diving reflex indexes. The diving reflex indexes were the peak value of the R–R interval during the test (R–Rmax) and the relative difference between the baseline and peak response due to the test (R–Rchange). Odds ratios and 95% confidence intervals for the prevalence of prediabetes and diabetes were obtained using logistic regression models while adjusting for sex, age, body fat percentage, family history of diabetes, smoking status, and drinking status, sleeping hours, energy intake, and peak oxygen uptake. Results: Forty-one participants had prediabetes (n=24) or diabetes (n=17). Using the lowest diving reflex indexes as reference, we calculated odds ratios and 95% confidence intervals for the outcomes if interests. We found inverse relationships between R-Rmax and prediabetes and diabetes (P for trend = 0.104) as well as R-Rchange and diabetes (P for trend = 0.023). Conclusions: In this cross-sectional analysis, the data suggest diving reflex indexes, especially R-Rchange, may be related to the prevalence of diabetes." @default.
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• W4387020198 date "2023-09-25" @default.
• W4387020198 modified "2023-09-26" @default.
• W4387020198 title "Parasympathetic nervous function and prevalence of prediabetes/diabetes mellitus: a cross-sectional study: WASEDA'S Health Study" @default.
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• W4387020198 doi "https://doi.org/10.21203/rs.3.rs-3330777/v1" @default.
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