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• W4387020618 abstract "There are three excellent articles in the issue, including a cross-sectional study to assess the impact of coronavirus disease (COVID-19) infection on pulmonary function tests in children,[1] a case report of high-frequency ventilation in an infant with acute respiratory distress syndrome due to pneumocystis pneumonia,[2] and an overview of the vitamin D deficiency and its impact on respiratory health in the Hong Kong pediatric population.[3] Lung injuries related to COVID-19 have been widely reported, and there are concerns regarding the assessment of lung injury for discharged patients. Approximately one-third of pediatric patients show ground glass opacities in lung imaging, which correlates with clinical severity. However, there is a lack of pediatric data in Southeast Asia regarding the long-term consequences of COVID-19 infection on lung function. Dr. Archana Kumari conducted a study to evaluate the long-term impact of COVID-19 on lung function in children.[1] The study enrolled 20 children aged 7‐18 years, with varying degrees of disease severity, at an average of 8.3 ± 2 months (range 7‐14 months) after COVID-19. The results showed that all children had normal respiratory rate, SpO2, and chest auscultation. The mean blood oxygen saturation. Lung function tests, including forced expiratory volume in one second (FEV1), forced expiratory volume in 0.5s, FEV1/forced vital capacity, and peak expiratory flow rate, were all within the normal range, even across different subgroups. Children with mild to moderate infections not exhibited long-term sequelae. This study provided valuable information regarding the long-term effects of COVID-19 infection on lung function in children. They contribute to a better understanding for pediatricians in assessing and managing lung function issues in children after COVID-19 infection. However, due to the small sample size and single-region inclusion, further research is needed to validate and expand upon these results. The second article reports a case of a 9-month-old infant with Kaposiform hemangioendothelioma and Kasabach‐Merritt syndrome who developed acute respiratory distress syndrome suspected caused by Pneumocystis jirovecii infection during chemotherapy and prednisolone treatment.[2] The patient received high-frequency oscillatory ventilation (HFOV) due to traditional ventilator failure. On the 28th day of hospitalization, successful extubation was achieved. This report suggests that HFOV may serve as an alternative treatment modality for pediatric patients with severe respiratory failure and excessively high ventilatory settings in the context of P. jirovecii infection. HFOV provides a lung-protective strategy by increasing mean airway pressures to maintain oxygenation while minimizing ventilation-induced lung injury. It is important to note that this is a case report, and the conclusions are based on a single patient. Further research is needed to validate the efficacy and safety of this approach. The third article has reviewed the status of vitamin D deficiency (VDD) in the pediatric population in Hong Kong.[3] VDD is a common phenomenon in the world. The negative impact of VDD on bone health, such as increasing the risk of osteoporosis or osteopenia in adults and rickets in children, is well-known. Emerging evidences support the negative non-skeletal effects of VDD, such as an increased risk of infections, cancer, and autoimmune diseases. Considering the potential impact of VDD on the respiratory system, this review article provides important information on the prevalence of VDD and its impact on respiratory health in the pediatric population in Hong Kong. It highlights the potential benefits of vitamin D supplementation in improving VDD. However, due to limited study quality, further research is still needed to get a more comprehensive understanding of the effects of VDD and the optimal treatment strategies. In clinical practice, assessing individual risk factors for VDD and appropriately supplementing vitamin D may be worth considering. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest." @default.
• W4387020618 created "2023-09-26" @default.
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• W4387020618 date "2023-01-01" @default.
• W4387020618 modified "2023-09-26" @default.
• W4387020618 title "Editorial" @default.
• W4387020618 doi "https://doi.org/10.4103/prcm.prcm_20_23" @default.
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