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• W4387022729 abstract "Background : The prevalence of biopsy-proven renal disease varies with geographical regions as well as within the same country and and with demographic factors such as age, gender, race, socioeconomic status and indications for renal biopsy. Thus, there is a great variation in the presentation of Glomerular disease across the globe and the disease spectrum has also been changing over the last few decades. 1) To determine the spectrum and clinical prol Objectives: e of different glomerular diseases. 2) To look for correlation between clinical features to nal histopathological diagnosis. Methodology: This was single center cross sectional prospective observational study done over 1 year period. Clinical presentation and histopathological correlation of 125 kidney biopsies for adult glomerular diseases were analysed. The average age of patients was 39.27±15.43 years. 55.2% of t Results: hem belong to the age group 31-60 years. Females predominate and comprises 56% of cases. Most common clinical syndrome observed was nephrotic syndrome (31.2%) followed by rapidly progressing renal failure (20%), nephrotic nephritic syndrome (13.6%), acute nephritic syndrome (12.8%), acute kidney injury (8.8%), asymptomatic urinary abnormalities (8%) and chronic kidney disease (5.6%). Lupus nephritis (24%) was the most common histological diagnosis followed by crescentic GN (15.2%), IgAN (13.6%), minimal change disease (8.8%) and FSGS (8.8%). Lupus nephritis was also the most common biopsy diagnosis in the age group of 18 to 30 years, while crescentic GN was the most common histological diagnosis in the elderly group >60 years. 30 cases (24%) required dialysis, at the time of biopsy, 60% of them belong to RPRF group with average serum creatinine of 8.51 mg/dl. Primary GD was seen in 53.6% cases and the most common primary GD was IgAN (25.4%). Secondary GD was seen in 46.4% of the cases and lupus nephritis (51.7%) was the most common cause. IgAN, MCD, MN, FSGS were seen more in males while lupus nephritis, crescentic GN and brillary GN were more common in females. Most common glomerular disease presenting as nephrotic syndrome was MCD (28.2%) followed by FSGS (17.9%). Most common biopsy diagnosis in RPRF category was crescentic GN (60%) followed by IgAN (12%) and in the nephrotic nephritic syndrome and AUA group lupus nephritis contributed the most. 20 cases (16%) were diabetic and the most common biopsy diagnosis in them was diabetic nephropathy followed by IgAN. Lupus class IV was the commonest lesion observed followed by class IV+V in lupus nephritis patients." @default.
• W4387022729 created "2023-09-26" @default.
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• W4387022729 date "2023-09-01" @default.
• W4387022729 modified "2023-10-15" @default.
• W4387022729 title "A STUDY OF CLINICAL PRESENTATION AND CORRELATIVE HISTOPATHOLOGICAL PATTERNS IN GLOMERULAR DISEASES IN A TERTIARY CARE CENTRE IN NORTHEAST INDIA." @default.
• W4387022729 doi "https://doi.org/10.36106/ijar/2601163" @default.
• W4387022729 hasPublicationYear "2023" @default.
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