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- W4387024204 abstract "Abstract To investigate the association between pre-pregnancy body mass index (BMI) and the risk of macrosomia through a preconception-early pregnancy-birth cohort in China. From July 2018 to December 2021, we recruited a total of 12,254 women of childbearing age from the Northwest Women's and Children's Hospital of China. We collected basic demographic characteristics and lifestyle behavior information of the subjects through questionnaires and practical measurements, and conducted further follow-up for pregnancy outcomes. The study assessed the association of pre-pregnancy BMI with macrosomia using logistic regression models, and performed a linear trend test. Moreover, we utilized restricted cubic splines and polynomial regression to investigate the non-linear relationship of pre-pregnancy BMI with macrosomia. A total of 11438 subjects were included in this study and the prevalence of macrosomia among all infants was 5.64 per cent. The results indicated that, when compared to the normal weight group, the risk of macrosomia was higher in the overweight and obesity groups (overweight: (OR=1.66 (1.35-2.01)); obesity: (OR=1.66 (1.13-2.45))), and the risk of macrosomia was lower in the underweight group (OR=0.55 (0.41-0.73)). Additionally, similar findings were observed concerning the relationship between pre-pregnancy BMI and grade 1 macrosomia. The use of restricted cubic splines revealed that the prevalence of macrosomia/grade 1 macrosomia increased with rising pre-pregnancy BMI. Furthermore, when we stratified the data by covariates, the nonlinear relationship between pre-pregnancy BMI and macrosomia/grade 1 macrosomia persisted. The results of the polynomial regression showed a gradual increase in fetal birth weight with increasing pre-pregnancy BMI levels. Pre-pregnancy overweight and obesity were associated with higher risks of macrosomia. Therefore, it indicates that it may be possible to decrease the risk of macrosomia through preconception weight regulation." @default.
- W4387024204 created "2023-09-26" @default.
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- W4387024204 date "2023-09-25" @default.
- W4387024204 modified "2023-09-26" @default.
- W4387024204 title "The association of maternal pre-pregnancy body mass index with macrosomia: a birth cohort study from China" @default.
- W4387024204 doi "https://doi.org/10.21203/rs.3.rs-3358027/v1" @default.
- W4387024204 hasPublicationYear "2023" @default.
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