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- W4387024462 abstract "Single-particle cryo-electron microscopy (cryo-EM SPA) has recently emerged as an exceptionally well-suited technique for determining the structure of membrane proteins (MPs). Indeed, in the last years, it was observed a huge increase in the number of MPs solved by cryo-EM SPA at a resolution better than 3.0 Å in the Protein Data Bank (PDB). However, sample preparation remains a significant challenge in the field. Here, we evaluated in the MPs solved by cryo-EM SPA deposited in the PDB in the last two years at a resolution below 3.0 Å the most critical parameters for sample preparation: i) the surfactant used for protein extraction from the membrane, ii) the surfactant, amphiphiles, nanodiscs or other molecules present in the vitrification step, iii) the vitrification method employed, and iv) the type of grids used. The aim is not to provide a definitive answer on the optimal sample conditions for cryo-EM SPA of MPs, but rather assess the current trends in the MP structural biology community towards obtaining high-resolution cryo-EM structures." @default.
- W4387024462 created "2023-09-26" @default.
- W4387024462 creator A5007947124 @default.
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- W4387024462 date "2023-09-22" @default.
- W4387024462 modified "2023-10-18" @default.
- W4387024462 title "Overview of Membrane Protein Sample Preparation for Single-Particle Cryo-Electron Microscopy Analysis" @default.
- W4387024462 doi "https://doi.org/10.20944/preprints202308.1386.v2" @default.
- W4387024462 hasPublicationYear "2023" @default.
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