FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387025527> ?p ?o ?g. }

• W4387025527 endingPage "2655" @default.
• W4387025527 startingPage "2643" @default.
• W4387025527 abstract "Abstract Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver disease and the prevalence is rising, especially in women. Although during reproductive age women are protected against FLD, for still unknown and understudied reasons some develop rapidly progressive disease at the menopause. The patatin-like phospholipase domain-containing 3 ( PNPLA3 ) p.I148M variant accounts for the largest fraction of inherited FLD variability. In the present study, we show that there is a specific multiplicative interaction between female sex and PNPLA3 p.I148M in determining FLD in at-risk individuals (steatosis and fibrosis, P < 10 −10 ; advanced fibrosis/hepatocellular carcinoma, P = 0.034) and in the general population ( P < 10 −7 for alanine transaminase levels). In individuals with obesity, hepatic PNPLA3 expression was higher in women than in men ( P = 0.007) and in mice correlated with estrogen levels. In human hepatocytes and liver organoids, PNPLA3 was induced by estrogen receptor-α (ER-α) agonists. By chromatin immunoprecipitation and luciferase assays, we identified and characterized an ER-α-binding site within a PNPLA3 enhancer and demonstrated via CRISPR–Cas9 genome editing that this sequence drives PNPLA3 p.I148M upregulation, leading to lipid droplet accumulation and fibrogenesis in three-dimensional multilineage spheroids with stellate cells. These data suggest that a functional interaction between ER-α and PNPLA3 p.I148M variant contributes to FLD in women." @default.
• W4387025527 created "2023-09-26" @default.
• W4387025527 creator A5001362811 @default.
• W4387025527 creator A5002825121 @default.
• W4387025527 creator A5004290937 @default.
• W4387025527 creator A5005284630 @default.
• W4387025527 creator A5006690165 @default.
• W4387025527 creator A5007639428 @default.
• W4387025527 creator A5011745084 @default.
• W4387025527 creator A5020425919 @default.
• W4387025527 creator A5020610956 @default.
• W4387025527 creator A5024454873 @default.
• W4387025527 creator A5024750114 @default.
• W4387025527 creator A5028079440 @default.
• W4387025527 creator A5031667568 @default.
• W4387025527 creator A5034125351 @default.
• W4387025527 creator A5037073590 @default.
• W4387025527 creator A5038002101 @default.
• W4387025527 creator A5038089814 @default.
• W4387025527 creator A5039389628 @default.
• W4387025527 creator A5040277868 @default.
• W4387025527 creator A5042231442 @default.
• W4387025527 creator A5042383683 @default.
• W4387025527 creator A5043126366 @default.
• W4387025527 creator A5044818409 @default.
• W4387025527 creator A5045588634 @default.
• W4387025527 creator A5046105984 @default.
• W4387025527 creator A5048054475 @default.
• W4387025527 creator A5050497878 @default.
• W4387025527 creator A5054402082 @default.
• W4387025527 creator A5055005038 @default.
• W4387025527 creator A5055908265 @default.
• W4387025527 creator A5056375128 @default.
• W4387025527 creator A5057596539 @default.
• W4387025527 creator A5057634923 @default.
• W4387025527 creator A5062103932 @default.
• W4387025527 creator A5066500041 @default.
• W4387025527 creator A5069060952 @default.
• W4387025527 creator A5073140074 @default.
• W4387025527 creator A5075129525 @default.
• W4387025527 creator A5075520666 @default.
• W4387025527 creator A5077581127 @default.
• W4387025527 creator A5084672249 @default.
• W4387025527 creator A5085747588 @default.
• W4387025527 creator A5086600832 @default.
• W4387025527 creator A5087240808 @default.
• W4387025527 creator A5091506479 @default.
• W4387025527 creator A5091751475 @default.
• W4387025527 creator A5092937483 @default.
• W4387025527 creator A5092937484 @default.
• W4387025527 creator A5092937485 @default.
• W4387025527 date "2023-09-25" @default.
• W4387025527 modified "2023-10-18" @default.
• W4387025527 title "Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women" @default.
• W4387025527 cites W1830916533 @default.
• W4387025527 cites W1932257584 @default.
• W4387025527 cites W1998155250 @default.
• W4387025527 cites W1999574084 @default.
• W4387025527 cites W2012644882 @default.
• W4387025527 cites W2013654496 @default.
• W4387025527 cites W2017511982 @default.
• W4387025527 cites W2022779434 @default.
• W4387025527 cites W2030379010 @default.
• W4387025527 cites W2030525320 @default.
• W4387025527 cites W2031383572 @default.
• W4387025527 cites W2045688706 @default.
• W4387025527 cites W2050602528 @default.
• W4387025527 cites W2067740038 @default.
• W4387025527 cites W2070056761 @default.
• W4387025527 cites W2071991978 @default.
• W4387025527 cites W2082704080 @default.
• W4387025527 cites W2085652695 @default.
• W4387025527 cites W2099990122 @default.
• W4387025527 cites W2100573537 @default.
• W4387025527 cites W2115375080 @default.
• W4387025527 cites W2118013260 @default.
• W4387025527 cites W2125128086 @default.
• W4387025527 cites W2139122477 @default.
• W4387025527 cites W2161584400 @default.
• W4387025527 cites W2162382402 @default.
• W4387025527 cites W2163445749 @default.
• W4387025527 cites W2179438025 @default.
• W4387025527 cites W2196772143 @default.
• W4387025527 cites W2204688218 @default.
• W4387025527 cites W2231585839 @default.
• W4387025527 cites W2262495123 @default.
• W4387025527 cites W2332857439 @default.
• W4387025527 cites W2343343747 @default.
• W4387025527 cites W2432815617 @default.
• W4387025527 cites W2531040022 @default.
• W4387025527 cites W2571018111 @default.
• W4387025527 cites W2607779679 @default.
• W4387025527 cites W2610476257 @default.
• W4387025527 cites W2616037908 @default.
• W4387025527 cites W2895486342 @default.
• W4387025527 cites W2912792291 @default.
• W4387025527 cites W2914775288 @default.
• W4387025527 cites W2924587279 @default.

• next