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- W4387026357 abstract "Background: Cutaneous tuberculosis (TB) presents in 1-2% of patients with TB[1,2]. A search of the UCSF electronic medical record from 2011-2020 for terms related to cutaneous TB/tuberculid produced 404 records. These were screened for history of (1) TB/any positive TB test associated with skin findings concerning for tuberculosis/tuberculid and/or (2) receipt of anti-TB therapy to treat a cutaneous process, yielding 24 cases. Exclusion of 19 putative tuberculids and nonspecific neutrophilic dermatoses produced a population of 5 cases with final clinical diagnosis of cutaneous tuberculosis. Morphology included subcutaneous nodules/plaques involving the trunk in 3 patients and extremities/buttocks in 2 patients. One patient had contiguous spread from pulmonary TB while the remaining 4 had primary cutaneous disease or unknown source. Final subtypes included 2 cases of scrofuloderma, 2 lupus vulgaris, and 1 miliary TB. Four patients had skin biopsies, all demonstrating granulomatous dermatitis with negative Fite stains. Skin tissue culture grew Mycobacterium tuberculosis (MTB) in 2 of 4 (50%) cases, including scrofuloderma and miliary TB. Where data was available, interferon-gamma release assay (IGRA) was positive in 4/4 (100%), purified protein derivative (PPD) positive in 4/5 (80%), and both positive in 3/3 (100%) of patients. All 5 patients were prescribed multidrug therapy, though only 3 had relevant follow up, with all 3 (100%) demonstrating dermatologic improvement by 8 weeks. While limited by incomplete data and small sample size, this study highlights the rarity and spectrum of cutaneous TB presentations over nearly 10 years at a US academic medical center." @default.
- W4387026357 created "2023-09-26" @default.
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- W4387026357 date "2023-09-01" @default.
- W4387026357 modified "2023-09-26" @default.
- W4387026357 title "44261 Cutaneous tuberculosis at a US academic medical center: A retrospective review" @default.
- W4387026357 doi "https://doi.org/10.1016/j.jaad.2023.07.581" @default.
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