FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387026900> ?p ?o ?g. }

• W4387026900 endingPage "176080" @default.
• W4387026900 startingPage "176080" @default.
• W4387026900 abstract "Licochalcone A (LCA) is a flavonoid isolated from Glycyrrhiza uralensis Fisch that has shown promising therapeutic effects in various cancers. This study attempted to analyze its therapeutic potential for esophageal cancer (EC). Combining multiple databases and network pharmacology, we found that the mechanism of LCA inhibiting EC may be closely related to p53 signaling pathway, cell cycle regulation and apoptosis. Molecular docking was then used to predict the affinity between LCA and key targets. Subsequently, we selected three common EC cell lines for in vitro validation. LCA treatment significantly inhibited EC cell proliferation and colony formation. Wound healing and transwell assay showed that LCA can reduce the migration and invasion of EC cells, and down-regulated the expression of matrix metalloproteinases (MMP). LCA promoted excessive ROS production, decreased mitochondrial membrane potential, and upregulated the expression of Bax, Caspase3 and Caspase-9, all of which are involved in apoptosis. LCA treatment blocked the cell cycle in G2/M phase and decreased the expression of cyclin D1, cyclin B1, and CDK1. LCA significantly up-regulated p53 protein and gene expression, thereby inducing apoptosis and cycle arrest. Finally, the xenograft tumor model was established by subcutaneous injection of Eca-109 cells. LCA administration inhibited tumor growth by activating p53 signaling pathways and apoptosis. Meanwhile, there was no significant weight loss and few major organotoxicity and hematotoxicity. In conclusion, LCA is an excellent candidate for EC treatment by regulating p53 pathway to induce G2/M phase arrest and apoptosis." @default.
• W4387026900 created "2023-09-26" @default.
• W4387026900 creator A5015348762 @default.
• W4387026900 creator A5025851882 @default.
• W4387026900 creator A5038171495 @default.
• W4387026900 creator A5056624492 @default.
• W4387026900 creator A5064023616 @default.
• W4387026900 creator A5078241517 @default.
• W4387026900 creator A5079564469 @default.
• W4387026900 creator A5083922241 @default.
• W4387026900 date "2023-11-01" @default.
• W4387026900 modified "2023-10-12" @default.
• W4387026900 title "Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study" @default.
• W4387026900 cites W1480039654 @default.
• W4387026900 cites W1967880683 @default.
• W4387026900 cites W2167807253 @default.
• W4387026900 cites W2327472703 @default.
• W4387026900 cites W2560123314 @default.
• W4387026900 cites W2599889833 @default.
• W4387026900 cites W2737970188 @default.
• W4387026900 cites W2770634084 @default.
• W4387026900 cites W2789001259 @default.
• W4387026900 cites W2794922249 @default.
• W4387026900 cites W2824108843 @default.
• W4387026900 cites W290854889 @default.
• W4387026900 cites W2915352116 @default.
• W4387026900 cites W2919971531 @default.
• W4387026900 cites W2938013875 @default.
• W4387026900 cites W2946829842 @default.
• W4387026900 cites W2951300266 @default.
• W4387026900 cites W2964401309 @default.
• W4387026900 cites W2965824070 @default.
• W4387026900 cites W2968772876 @default.
• W4387026900 cites W2982273522 @default.
• W4387026900 cites W2996486857 @default.
• W4387026900 cites W3003754048 @default.
• W4387026900 cites W3007126125 @default.
• W4387026900 cites W3015748690 @default.
• W4387026900 cites W3026903671 @default.
• W4387026900 cites W3105929256 @default.
• W4387026900 cites W3106476743 @default.
• W4387026900 cites W3110555302 @default.
• W4387026900 cites W3130566070 @default.
• W4387026900 cites W3133621310 @default.
• W4387026900 cites W3216989648 @default.
• W4387026900 cites W4371784450 @default.
• W4387026900 cites W4378745094 @default.
• W4387026900 doi "https://doi.org/10.1016/j.ejphar.2023.176080" @default.
• W4387026900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37758012" @default.
• W4387026900 hasPublicationYear "2023" @default.
• W4387026900 type Work @default.
• W4387026900 citedByCount "0" @default.
• W4387026900 crossrefType "journal-article" @default.
• W4387026900 hasAuthorship W4387026900A5015348762 @default.
• W4387026900 hasAuthorship W4387026900A5025851882 @default.
• W4387026900 hasAuthorship W4387026900A5038171495 @default.
• W4387026900 hasAuthorship W4387026900A5056624492 @default.
• W4387026900 hasAuthorship W4387026900A5064023616 @default.
• W4387026900 hasAuthorship W4387026900A5078241517 @default.
• W4387026900 hasAuthorship W4387026900A5079564469 @default.
• W4387026900 hasAuthorship W4387026900A5083922241 @default.
• W4387026900 hasConcept C104317684 @default.
• W4387026900 hasConcept C105696609 @default.
• W4387026900 hasConcept C120504264 @default.
• W4387026900 hasConcept C127561419 @default.
• W4387026900 hasConcept C185592680 @default.
• W4387026900 hasConcept C190283241 @default.
• W4387026900 hasConcept C199835354 @default.
• W4387026900 hasConcept C29537977 @default.
• W4387026900 hasConcept C502942594 @default.
• W4387026900 hasConcept C55493867 @default.
• W4387026900 hasConcept C62112901 @default.
• W4387026900 hasConcept C86803240 @default.
• W4387026900 hasConcept C95444343 @default.
• W4387026900 hasConcept C98274493 @default.
• W4387026900 hasConceptScore W4387026900C104317684 @default.
• W4387026900 hasConceptScore W4387026900C105696609 @default.
• W4387026900 hasConceptScore W4387026900C120504264 @default.
• W4387026900 hasConceptScore W4387026900C127561419 @default.
• W4387026900 hasConceptScore W4387026900C185592680 @default.
• W4387026900 hasConceptScore W4387026900C190283241 @default.
• W4387026900 hasConceptScore W4387026900C199835354 @default.
• W4387026900 hasConceptScore W4387026900C29537977 @default.
• W4387026900 hasConceptScore W4387026900C502942594 @default.
• W4387026900 hasConceptScore W4387026900C55493867 @default.
• W4387026900 hasConceptScore W4387026900C62112901 @default.
• W4387026900 hasConceptScore W4387026900C86803240 @default.
• W4387026900 hasConceptScore W4387026900C95444343 @default.
• W4387026900 hasConceptScore W4387026900C98274493 @default.
• W4387026900 hasLocation W43870269001 @default.
• W4387026900 hasLocation W43870269002 @default.
• W4387026900 hasOpenAccess W4387026900 @default.
• W4387026900 hasPrimaryLocation W43870269001 @default.
• W4387026900 hasRelatedWork W1972085353 @default.
• W4387026900 hasRelatedWork W1995228374 @default.
• W4387026900 hasRelatedWork W2005714030 @default.
• W4387026900 hasRelatedWork W2347624711 @default.
• W4387026900 hasRelatedWork W2366424044 @default.

• next