Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387030206> ?p ?o ?g. }
- W4387030206 endingPage "e621" @default.
- W4387030206 startingPage "e611" @default.
- W4387030206 abstract "BackgroundVascular fibrosis is a key manifestation of systemic sclerosis that leads to the narrowing of small and medium arteries, causing vascular clinical manifestations including digital ulcers and pulmonary arterial hypertension. We investigated the potential of the MRI-based Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of vascular fibrosis by using it to quantify and predict the burden of digital ulcer disease in patients with systemic sclerosis.MethodsTwo independent cohorts of patients participating in the prospective observational study STRIKE were consecutively enrolled from the Scleroderma Clinic of the Leeds Teaching Hospitals Trust, Leeds, UK. Eligible patients were aged 18 years or older and fulfilled the very early diagnosis of systemic sclerosis (VEDOSS) or the 2013 American College of Rheumatology (ACR)–European Alliance of Associations for Rheumatology (EULAR) systemic sclerosis classification criteria. DAVIX was calculated as the percentage mean of the ratio of digital artery volume to finger volume in the four fingers of the dominant hand. Data were collected at baseline and 12-month follow-up, and the primary outcome was the presence of digital ulcers at 12-month follow-up.FindingsBetween Feb 7, 2018, and April 11, 2022, we included 85 patients in the exploratory cohort and 150 in the validation cohort. In the exploratory cohort, the mean age was 54·5 years (SD 11·6), 75 (88%) of 85 patients were women, ten (12%) were men, and 69 (82%) were White. In the validation cohort, the mean age was 53·5 years (SD 13·8), 136 (91%) of 150 patients were women, 14 (9%) were men, and 127 (85%) were White. In the exploratory cohort, DAVIX was significantly lower in patients with previous or active digital ulcers (0·34% [IQR 0·16–0·69]) than in those without digital ulcer disease (0·65% [0·42–0·88]; p=0·015); this finding was substantiated in the validation cohort (0·43% [0·20–0·73] vs 0·73% [0·53–0·97]; p<0·0001). Patients who developed new digital ulcers during 12-month follow-up had a lower DAVIX (0·23% [0·10–0·66]) than those who did not (0·65% [0·45–0·91]; p=0·0039). DAVIX was negatively correlated with disease duration (r=−0·415; p<0·0001), the ratio of forced vital capacity to the diffusing capacity of the lungs for carbon monoxide (r=−0·334; p=0·0091), nailfold capillaroscopy pattern (r=−0·447; p<0·0001), and baseline modified Rodnan skin score (r=−0·305; p=0·014) and was positively correlated with the diffusing capacity of carbon monoxide (r=0·368; p=0·0041). DAVIX was negatively correlated with change in score on the Scleroderma Health Assessment Questionnaire-Disability Index (r=−0·308; p=0·024), Visual Analogue Scale (VAS) Raynaud's (r=−0·271; p=0·044), and VAS digital ulcers (r=−0·291; p=0·044).InterpretationDAVIX is a promising surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis. The ability of DAVIX to non-invasively predict future digital ulcers and worsening of patient-reported outcomes could aid patient enrichment and stratification in clinical trials. Clinically, DAVIX could offer insights into the assessment of vascular activity. The sensitivity of DAVIX to change over time and with treatment will establish its value as an imaging outcome measure of vascular disease.FundingNational Institute for Health Research Biomedical Research Centre and University of Leeds Industry Engagement Accelerator Fund." @default.
- W4387030206 created "2023-09-26" @default.
- W4387030206 creator A5007587814 @default.
- W4387030206 creator A5010681869 @default.
- W4387030206 creator A5013253525 @default.
- W4387030206 creator A5017653274 @default.
- W4387030206 creator A5035954465 @default.
- W4387030206 creator A5040451649 @default.
- W4387030206 creator A5049837115 @default.
- W4387030206 creator A5052234978 @default.
- W4387030206 creator A5054615838 @default.
- W4387030206 creator A5065340464 @default.
- W4387030206 creator A5076854409 @default.
- W4387030206 creator A5092113278 @default.
- W4387030206 date "2023-10-01" @default.
- W4387030206 modified "2023-10-03" @default.
- W4387030206 title "MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study" @default.
- W4387030206 cites W1531955991 @default.
- W4387030206 cites W1540350711 @default.
- W4387030206 cites W1970780902 @default.
- W4387030206 cites W1973660879 @default.
- W4387030206 cites W1976388151 @default.
- W4387030206 cites W2004008756 @default.
- W4387030206 cites W2032839364 @default.
- W4387030206 cites W2051576146 @default.
- W4387030206 cites W2096579040 @default.
- W4387030206 cites W2126446504 @default.
- W4387030206 cites W2133170327 @default.
- W4387030206 cites W2150626870 @default.
- W4387030206 cites W2161648974 @default.
- W4387030206 cites W2164096595 @default.
- W4387030206 cites W2594954243 @default.
- W4387030206 cites W2794872743 @default.
- W4387030206 cites W2945166311 @default.
- W4387030206 cites W2986802032 @default.
- W4387030206 cites W3006838147 @default.
- W4387030206 cites W3035058168 @default.
- W4387030206 cites W3049603490 @default.
- W4387030206 cites W3154530887 @default.
- W4387030206 cites W3166611636 @default.
- W4387030206 cites W3212559415 @default.
- W4387030206 cites W3216565782 @default.
- W4387030206 cites W4211001791 @default.
- W4387030206 doi "https://doi.org/10.1016/s2665-9913(23)00189-3" @default.
- W4387030206 hasPublicationYear "2023" @default.
- W4387030206 type Work @default.
- W4387030206 citedByCount "1" @default.
- W4387030206 countsByYear W43870302062023 @default.
- W4387030206 crossrefType "journal-article" @default.
- W4387030206 hasAuthorship W4387030206A5007587814 @default.
- W4387030206 hasAuthorship W4387030206A5010681869 @default.
- W4387030206 hasAuthorship W4387030206A5013253525 @default.
- W4387030206 hasAuthorship W4387030206A5017653274 @default.
- W4387030206 hasAuthorship W4387030206A5035954465 @default.
- W4387030206 hasAuthorship W4387030206A5040451649 @default.
- W4387030206 hasAuthorship W4387030206A5049837115 @default.
- W4387030206 hasAuthorship W4387030206A5052234978 @default.
- W4387030206 hasAuthorship W4387030206A5054615838 @default.
- W4387030206 hasAuthorship W4387030206A5065340464 @default.
- W4387030206 hasAuthorship W4387030206A5076854409 @default.
- W4387030206 hasAuthorship W4387030206A5092113278 @default.
- W4387030206 hasBestOaLocation W43870302061 @default.
- W4387030206 hasConcept C126322002 @default.
- W4387030206 hasConcept C141071460 @default.
- W4387030206 hasConcept C142724271 @default.
- W4387030206 hasConcept C180032290 @default.
- W4387030206 hasConcept C188816634 @default.
- W4387030206 hasConcept C198451711 @default.
- W4387030206 hasConcept C201903717 @default.
- W4387030206 hasConcept C2779967694 @default.
- W4387030206 hasConcept C71924100 @default.
- W4387030206 hasConcept C72563966 @default.
- W4387030206 hasConceptScore W4387030206C126322002 @default.
- W4387030206 hasConceptScore W4387030206C141071460 @default.
- W4387030206 hasConceptScore W4387030206C142724271 @default.
- W4387030206 hasConceptScore W4387030206C180032290 @default.
- W4387030206 hasConceptScore W4387030206C188816634 @default.
- W4387030206 hasConceptScore W4387030206C198451711 @default.
- W4387030206 hasConceptScore W4387030206C201903717 @default.
- W4387030206 hasConceptScore W4387030206C2779967694 @default.
- W4387030206 hasConceptScore W4387030206C71924100 @default.
- W4387030206 hasConceptScore W4387030206C72563966 @default.
- W4387030206 hasIssue "10" @default.
- W4387030206 hasLocation W43870302061 @default.
- W4387030206 hasOpenAccess W4387030206 @default.
- W4387030206 hasPrimaryLocation W43870302061 @default.
- W4387030206 hasRelatedWork W2042664817 @default.
- W4387030206 hasRelatedWork W2750095015 @default.
- W4387030206 hasRelatedWork W2943558117 @default.
- W4387030206 hasRelatedWork W2950998089 @default.
- W4387030206 hasRelatedWork W3116131585 @default.
- W4387030206 hasRelatedWork W3176033318 @default.
- W4387030206 hasRelatedWork W4254169278 @default.
- W4387030206 hasRelatedWork W4281965648 @default.
- W4387030206 hasRelatedWork W4313590353 @default.
- W4387030206 hasRelatedWork W4226344455 @default.
- W4387030206 hasVolume "5" @default.
- W4387030206 isParatext "false" @default.