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• W4387033021 startingPage "87" @default.
• W4387033021 abstract "KDM4 histone demethylases mainly catalyze the removal of methyl marks from H3K9 and H3K36 to epigenetically regulate chromatin structure and gene expression. KDM4 expression is strictly regulated to ensure proper function in a myriad of biological processes, including transcription, cellular proliferation and differentiation, DNA damage repair, immune response, and stem cell self-renewal. Aberrant expression of KDM4 demethylase has been documented in many types of blood and solid tumors, and thus, KDM4s represent promising therapeutic targets. In this chapter, we summarize the current knowledge of the structures and regulatory mechanisms of KDM4 proteins and our understanding of their alterations in human pathological processes with a focus on development and cancer. We also review the reported KDM4 inhibitors and discuss their potential as therapeutic agents." @default.
• W4387033021 created "2023-09-27" @default.
• W4387033021 creator A5002131323 @default.
• W4387033021 creator A5013135288 @default.
• W4387033021 creator A5066745034 @default.
• W4387033021 date "2023-01-01" @default.
• W4387033021 modified "2023-10-16" @default.
• W4387033021 title "KDM4 Demethylases: Structure, Function, and Inhibitors" @default.
• W4387033021 cites W1088813759 @default.
• W4387033021 cites W1558747208 @default.
• W4387033021 cites W1606839606 @default.
• W4387033021 cites W1831392484 @default.
• W4387033021 cites W1918857920 @default.
• W4387033021 cites W1963909260 @default.
• W4387033021 cites W1967381498 @default.
• W4387033021 cites W1968884438 @default.
• W4387033021 cites W1969233368 @default.
• W4387033021 cites W1970032012 @default.
• W4387033021 cites W1971561248 @default.
• W4387033021 cites W1973034705 @default.
• W4387033021 cites W1973602401 @default.
• W4387033021 cites W1977995427 @default.
• W4387033021 cites W1978027379 @default.
• W4387033021 cites W1979658237 @default.
• W4387033021 cites W1981361342 @default.
• W4387033021 cites W1982409009 @default.
• W4387033021 cites W1983876698 @default.
• W4387033021 cites W1984109291 @default.
• W4387033021 cites W1990949301 @default.
• W4387033021 cites W1992538495 @default.
• W4387033021 cites W1993582197 @default.
• W4387033021 cites W2001401534 @default.
• W4387033021 cites W2002012961 @default.
• W4387033021 cites W2012034410 @default.
• W4387033021 cites W2014696364 @default.
• W4387033021 cites W2015985284 @default.
• W4387033021 cites W2016661249 @default.
• W4387033021 cites W2017308570 @default.
• W4387033021 cites W2018919886 @default.
• W4387033021 cites W2024195722 @default.
• W4387033021 cites W2026496126 @default.
• W4387033021 cites W2027661795 @default.
• W4387033021 cites W2028626225 @default.
• W4387033021 cites W2030041716 @default.
• W4387033021 cites W2030692354 @default.
• W4387033021 cites W2032002811 @default.
• W4387033021 cites W2032463383 @default.
• W4387033021 cites W2033194905 @default.
• W4387033021 cites W2036504531 @default.
• W4387033021 cites W2037535431 @default.
• W4387033021 cites W2039185178 @default.
• W4387033021 cites W2040025688 @default.
• W4387033021 cites W2040801912 @default.
• W4387033021 cites W2041992457 @default.
• W4387033021 cites W2043823295 @default.
• W4387033021 cites W2047181533 @default.
• W4387033021 cites W2054621094 @default.
• W4387033021 cites W2056842797 @default.
• W4387033021 cites W2059059097 @default.
• W4387033021 cites W2063982921 @default.
• W4387033021 cites W2064237195 @default.
• W4387033021 cites W2066715607 @default.
• W4387033021 cites W2068157186 @default.
• W4387033021 cites W2077082854 @default.
• W4387033021 cites W2077981176 @default.
• W4387033021 cites W2079304435 @default.
• W4387033021 cites W2080954244 @default.
• W4387033021 cites W2082387950 @default.
• W4387033021 cites W2085005232 @default.
• W4387033021 cites W2085544097 @default.
• W4387033021 cites W2086342381 @default.
• W4387033021 cites W2086469988 @default.
• W4387033021 cites W2092371815 @default.
• W4387033021 cites W2093958416 @default.
• W4387033021 cites W2094221767 @default.
• W4387033021 cites W2096283457 @default.
• W4387033021 cites W2105718456 @default.
• W4387033021 cites W2106208936 @default.
• W4387033021 cites W2106921118 @default.
• W4387033021 cites W2107816126 @default.
• W4387033021 cites W2108928320 @default.
• W4387033021 cites W2113443914 @default.
• W4387033021 cites W2114505219 @default.
• W4387033021 cites W2114843025 @default.
• W4387033021 cites W2122889756 @default.
• W4387033021 cites W2123407675 @default.
• W4387033021 cites W2125765631 @default.
• W4387033021 cites W2130157550 @default.
• W4387033021 cites W2130983930 @default.
• W4387033021 cites W2132877013 @default.
• W4387033021 cites W2134675668 @default.
• W4387033021 cites W2135422714 @default.
• W4387033021 cites W2138992920 @default.
• W4387033021 cites W2142362590 @default.
• W4387033021 cites W2144275955 @default.
• W4387033021 cites W2144867041 @default.
• W4387033021 cites W2149441684 @default.
• W4387033021 cites W2154085129 @default.

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