Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387033364> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4387033364 abstract "Severe cutaneous adverse drug reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are challenging to be early diagnosed and evaluate their prognoses. This investigation aimed to analyse the expression profiles of SJS/TEN in peripheral blood mononuclear cells (PBMC) and assess the correlation between circular RNA (circRNA) and disease severity. Sixteen SJS/TEN patients and sixteen controls were enrolled and serum samples of both groups were obtained. CircRNA expression profiles in three SJS/TEN patients and three controls were detected by RNA sequencing and bioinformatic analyses were then performed. The differentially expressed circRNAs were verified by quantitative polymerase chain reaction (qPCR). Then, analysing the correlation of circRNAs with the toxic epidermal necrolysis-specific severity of illness score (SCORTEN) and the epidermal detachment area. A total of 134 circRNAs were differentially expressed in the PBMCs of SJS/TEN individuals, according to our results. The qPCR showed that three circRNAs (hsa_circ_0000711, hsa_circ_0083619 and hsa_circ_0005615) were down-regulated, and one circRNA (hsa_circ_0003028) was up-regulated, which were compatible with the sequencing findings. The concentration of hsa_circ_0083619 was closely associated with the SCORTEN scale (r = -0.581, p = 0.037) and the epidermal detachment area (r = -0.576, p = 0.039). The circRNA-miRNA-mRNA prediction network was used to construct the hsa_circ_0083619/miR-18a-5p/BCL2L10 axis. The hsa_circ_0083619 could serve as a disease severity indicator for SJS/TEN. Through bioinformatics analysis, we speculated that hsa_circ_0083619/miR-18a-5p/BCL2L10 axis might play a role in SJS/TEN pathogenesis." @default.
- W4387033364 created "2023-09-27" @default.
- W4387033364 creator A5012062669 @default.
- W4387033364 creator A5032499056 @default.
- W4387033364 creator A5051307521 @default.
- W4387033364 creator A5059588624 @default.
- W4387033364 creator A5073396030 @default.
- W4387033364 creator A5078974578 @default.
- W4387033364 creator A5084558202 @default.
- W4387033364 date "2023-09-25" @default.
- W4387033364 modified "2023-09-27" @default.
- W4387033364 title "Analysis of <scp>circRNA</scp> profiles and clinical value in <scp>Stevens‐Johnson</scp> syndrome and toxic epidermal necrolysis" @default.
- W4387033364 cites W1977258127 @default.
- W4387033364 cites W1979259860 @default.
- W4387033364 cites W2005422908 @default.
- W4387033364 cites W2016283456 @default.
- W4387033364 cites W2045391651 @default.
- W4387033364 cites W2050431327 @default.
- W4387033364 cites W2062667403 @default.
- W4387033364 cites W2064165694 @default.
- W4387033364 cites W2070486804 @default.
- W4387033364 cites W2109696646 @default.
- W4387033364 cites W2400617335 @default.
- W4387033364 cites W2564945703 @default.
- W4387033364 cites W2768975831 @default.
- W4387033364 cites W2892630678 @default.
- W4387033364 cites W2946101009 @default.
- W4387033364 cites W2956525957 @default.
- W4387033364 cites W3006437689 @default.
- W4387033364 cites W3020976290 @default.
- W4387033364 cites W3174434142 @default.
- W4387033364 cites W3198765778 @default.
- W4387033364 cites W3211858868 @default.
- W4387033364 cites W4223569653 @default.
- W4387033364 cites W4296801542 @default.
- W4387033364 cites W4311730287 @default.
- W4387033364 cites W4321508824 @default.
- W4387033364 doi "https://doi.org/10.1111/exd.14939" @default.
- W4387033364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37750014" @default.
- W4387033364 hasPublicationYear "2023" @default.
- W4387033364 type Work @default.
- W4387033364 citedByCount "0" @default.
- W4387033364 crossrefType "journal-article" @default.
- W4387033364 hasAuthorship W4387033364A5012062669 @default.
- W4387033364 hasAuthorship W4387033364A5032499056 @default.
- W4387033364 hasAuthorship W4387033364A5051307521 @default.
- W4387033364 hasAuthorship W4387033364A5059588624 @default.
- W4387033364 hasAuthorship W4387033364A5073396030 @default.
- W4387033364 hasAuthorship W4387033364A5078974578 @default.
- W4387033364 hasAuthorship W4387033364A5084558202 @default.
- W4387033364 hasBestOaLocation W43870333641 @default.
- W4387033364 hasConcept C104317684 @default.
- W4387033364 hasConcept C126322002 @default.
- W4387033364 hasConcept C137061746 @default.
- W4387033364 hasConcept C145059251 @default.
- W4387033364 hasConcept C153911025 @default.
- W4387033364 hasConcept C16005928 @default.
- W4387033364 hasConcept C185592680 @default.
- W4387033364 hasConcept C202751555 @default.
- W4387033364 hasConcept C2775893923 @default.
- W4387033364 hasConcept C2780664588 @default.
- W4387033364 hasConcept C2781197716 @default.
- W4387033364 hasConcept C3019646584 @default.
- W4387033364 hasConcept C48023723 @default.
- W4387033364 hasConcept C55493867 @default.
- W4387033364 hasConcept C71924100 @default.
- W4387033364 hasConcept C86803240 @default.
- W4387033364 hasConceptScore W4387033364C104317684 @default.
- W4387033364 hasConceptScore W4387033364C126322002 @default.
- W4387033364 hasConceptScore W4387033364C137061746 @default.
- W4387033364 hasConceptScore W4387033364C145059251 @default.
- W4387033364 hasConceptScore W4387033364C153911025 @default.
- W4387033364 hasConceptScore W4387033364C16005928 @default.
- W4387033364 hasConceptScore W4387033364C185592680 @default.
- W4387033364 hasConceptScore W4387033364C202751555 @default.
- W4387033364 hasConceptScore W4387033364C2775893923 @default.
- W4387033364 hasConceptScore W4387033364C2780664588 @default.
- W4387033364 hasConceptScore W4387033364C2781197716 @default.
- W4387033364 hasConceptScore W4387033364C3019646584 @default.
- W4387033364 hasConceptScore W4387033364C48023723 @default.
- W4387033364 hasConceptScore W4387033364C55493867 @default.
- W4387033364 hasConceptScore W4387033364C71924100 @default.
- W4387033364 hasConceptScore W4387033364C86803240 @default.
- W4387033364 hasLocation W43870333641 @default.
- W4387033364 hasLocation W43870333642 @default.
- W4387033364 hasOpenAccess W4387033364 @default.
- W4387033364 hasPrimaryLocation W43870333641 @default.
- W4387033364 hasRelatedWork W2135855393 @default.
- W4387033364 hasRelatedWork W2372848881 @default.
- W4387033364 hasRelatedWork W2389840305 @default.
- W4387033364 hasRelatedWork W2396336407 @default.
- W4387033364 hasRelatedWork W2411378979 @default.
- W4387033364 hasRelatedWork W2964188964 @default.
- W4387033364 hasRelatedWork W3030965478 @default.
- W4387033364 hasRelatedWork W3208327304 @default.
- W4387033364 hasRelatedWork W4386985452 @default.
- W4387033364 hasRelatedWork W4387033364 @default.
- W4387033364 isParatext "false" @default.
- W4387033364 isRetracted "false" @default.
- W4387033364 workType "article" @default.