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• W4387033993 startingPage "143" @default.
• W4387033993 abstract "Abstract Objectives To review the current evidence on the relationship between agents that affect bone homeostasis and dental implant failures. Materials and Methods Electronic searches for bisphosphonates, denosumab, methotrexate, corticosteroids, romosozumab, sunitinib, and bevacizumab were performed using PubMed, MEDLINE (OVID), EMBASE (OVID), Cochrane Central Register of Controlled Trials (Cochrane Library), Cochrane Oral Health Group Trials Register (Cochrane Library) and Web of Science (Thomson Reuters). Manual searches were also conducted to complement the digital searches for recent issues. Results Previous publications suggested that bisphosphonates do not compromise the survival of dental implants. However, one study documented an increased risk of implant failure in patients who had received high‐dose of intravenous bisphosphonate therapy after implant rehabilitation. There has been an issue of MRONJ around implants in patients who have successfully received implant therapy before and after antiresorptive therapy, leading to late implant failure. Despite evidence on the detrimental effects of denosumab, methotrexate and corticosteroids on bone metabolism, their role in implant survival is not conclusive. Conclusions At present, there is insufficient evidence to establish a potential connection between agents that affects bone homeostasis and implant failure. However, some studies have reported negative results for implant therapy. In addition, implant‐related sequestration in patients who received anti‐resorptive therapy, despite of successful osseointegration, is also noticeable. Although limited studies are available at present, clinicians should still carefully consider the potential hazards and take appropriate precautions to minimize the risks associated with the medications and implant therapy." @default.
• W4387033993 created "2023-09-27" @default.
• W4387033993 creator A5035093015 @default.
• W4387033993 creator A5042432201 @default.
• W4387033993 creator A5080344101 @default.
• W4387033993 creator A5088894874 @default.
• W4387033993 date "2023-09-01" @default.
• W4387033993 modified "2023-10-14" @default.
• W4387033993 title "Effect of agents affecting bone homeostasis on short‐ and long‐term implant failure" @default.
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