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• W4387035909 abstract "Glutathione (GSH) as one most abundant thiol, acts as important roles in regulating cellular redox activities, and various diseases are closely related with its abnormal levels. Thus, monitoring intracellular GSH levels is essential for understanding cellular metabolism of many related diseases. In this work, we firstly reported a new fluorescence turn-on sensor, which was capable of selectively, sensitively and rapid sensing GSH over other thiols, especially cysteine and homocysteine in solutions and living cells. A meso-aryltellurium boron dipyrromethene (BODIPY) was firstly designed and synthesized, which showed silenced emission due to an efficient photoinduced electron transfer (PET) process from electron-rich Te to BODIPY, and then upon exposure to GSH, the meso-Te-C bond could be rapidly cleaved by the thiol group of GSH, thus resulting in an obvious fluorescence “turn-on” phenomenon through inhibition of the PET effect. This probe exhibited excellent selectivity and sensitivity towards GSH with a short response time of 2 min, showing a remarkable fluorescence enhancement observed at 541 nm with a large fluorescence quantum yield increase from nearly 0 to 0.73 upon excitation at 500 nm in PBS/CH3CN (9/1, v/v). The detection limit towards GSH was further calculated to be 1.7 nM by the linear fluorescence change at 541 nm in the GSH-concentration ranging from 0 to 4 μM. Furthermore, its sensing mechanism was validated by using mass spectrometry, confirming the rapid cleavage of the Te–C bond by GSH. Finally, cell imaging experiments demonstrated that this probe could successfully detect GSH in living cells, highlighting its potential for rapid and sensitive detection of intracellular GSH level changes. Therefore, a new meso-aryltellurium-BODIPY fluorescence turn-on sensor was firstly developed, which could selectively, sensitively and fast detect cellular GSH over other thiols based on the rapid cleavage of the meso Te–C bond." @default.
• W4387035909 created "2023-09-27" @default.
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• W4387035909 date "2024-01-01" @default.
• W4387035909 modified "2023-10-02" @default.
• W4387035909 title "Meso-aryltellurium-BODIPY-based fluorescence turn-on probe for selective, sensitive and fast glutathione sensing in HepG2 cells" @default.
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• W4387035909 doi "https://doi.org/10.1016/j.talanta.2023.125251" @default.
• W4387035909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37776804" @default.
• W4387035909 hasPublicationYear "2024" @default.
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