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- W4387035933 endingPage "106893" @default.
- W4387035933 startingPage "106893" @default.
- W4387035933 abstract "Diverse drug design strategies viz. molecular hybridization, substituent installation, scaffold hopping, isosteric replacement, high-throughput screening, induction and separation of chirality, structure modifications of phytoconstituents and use of structural templates have been exhaustively leveraged in the last decade to load the chemical toolbox of PARP inhibitors. Resultantly, numerous promising scaffolds have been pinpointed that in turn have led to the resuscitation of the credence to PARP inhibitors as cancer therapeutics. This review briefly presents the physiological functions of PARPs, the pharmacokinetics, and pharmacodynamics, and the interaction profiles of FDA-approved PARP inhibitors. Comprehensively covered is the section on the drug design strategies employed by drug discovery enthusiasts for furnishing PARP inhibitors. The impact of structural variations in the template of designed scaffolds on enzymatic and cellular activity (structure–activity relationship studies) has been discussed. The insights gained through the biological evaluation such as profiling of physicochemical properties and in vitro ADME properties, PK assessments, and high-dose pharmacology are covered" @default.
- W4387035933 created "2023-09-27" @default.
- W4387035933 creator A5001046267 @default.
- W4387035933 creator A5027538061 @default.
- W4387035933 creator A5034215926 @default.
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- W4387035933 creator A5073711691 @default.
- W4387035933 creator A5083824973 @default.
- W4387035933 creator A5092940047 @default.
- W4387035933 date "2023-12-01" @default.
- W4387035933 modified "2023-10-16" @default.
- W4387035933 title "Small molecule tractable PARP inhibitors: Scaffold construction approaches, mechanistic insights and structure activity relationship" @default.
- W4387035933 cites W1517509748 @default.
- W4387035933 cites W1537637917 @default.
- W4387035933 cites W1538419182 @default.
- W4387035933 cites W1581618534 @default.
- W4387035933 cites W1925527451 @default.
- W4387035933 cites W1965006127 @default.
- W4387035933 cites W1966704219 @default.
- W4387035933 cites W1966928113 @default.
- W4387035933 cites W1967070632 @default.
- W4387035933 cites W1969177701 @default.
- W4387035933 cites W1970027695 @default.
- W4387035933 cites W1976860819 @default.
- W4387035933 cites W1986918210 @default.
- W4387035933 cites W1992476369 @default.
- W4387035933 cites W1994011134 @default.
- W4387035933 cites W1999206490 @default.
- W4387035933 cites W2002771949 @default.
- W4387035933 cites W2003308339 @default.
- W4387035933 cites W2006001375 @default.
- W4387035933 cites W2008748016 @default.
- W4387035933 cites W2012049551 @default.
- W4387035933 cites W2014035904 @default.
- W4387035933 cites W2014150894 @default.
- W4387035933 cites W2014696364 @default.
- W4387035933 cites W2018329608 @default.
- W4387035933 cites W2018346130 @default.
- W4387035933 cites W2019775979 @default.
- W4387035933 cites W2023997559 @default.
- W4387035933 cites W2030315579 @default.
- W4387035933 cites W2033667646 @default.
- W4387035933 cites W2035398180 @default.
- W4387035933 cites W2037316481 @default.
- W4387035933 cites W2037867164 @default.
- W4387035933 cites W2040971700 @default.
- W4387035933 cites W2048671791 @default.
- W4387035933 cites W2049566913 @default.
- W4387035933 cites W2057706543 @default.
- W4387035933 cites W2060002498 @default.
- W4387035933 cites W2061298493 @default.
- W4387035933 cites W2066204526 @default.
- W4387035933 cites W2066324618 @default.
- W4387035933 cites W2068887701 @default.
- W4387035933 cites W2070758111 @default.
- W4387035933 cites W2072528578 @default.
- W4387035933 cites W2073660843 @default.
- W4387035933 cites W2081630196 @default.
- W4387035933 cites W2082932840 @default.
- W4387035933 cites W2083984635 @default.
- W4387035933 cites W2087949216 @default.
- W4387035933 cites W2088849763 @default.
- W4387035933 cites W2090031006 @default.
- W4387035933 cites W2092807015 @default.
- W4387035933 cites W2105664288 @default.
- W4387035933 cites W2106059513 @default.
- W4387035933 cites W2106390123 @default.
- W4387035933 cites W2111365327 @default.
- W4387035933 cites W2126937732 @default.
- W4387035933 cites W2127209492 @default.
- W4387035933 cites W2135364719 @default.
- W4387035933 cites W2144847112 @default.
- W4387035933 cites W2151499633 @default.
- W4387035933 cites W2160073632 @default.
- W4387035933 cites W2160399783 @default.
- W4387035933 cites W2263418248 @default.
- W4387035933 cites W2323969866 @default.
- W4387035933 cites W2474664935 @default.
- W4387035933 cites W2514327980 @default.
- W4387035933 cites W2539944286 @default.
- W4387035933 cites W2557717244 @default.
- W4387035933 cites W2588135595 @default.
- W4387035933 cites W2595970569 @default.
- W4387035933 cites W2607225256 @default.
- W4387035933 cites W2607668193 @default.
- W4387035933 cites W2609549213 @default.
- W4387035933 cites W2612428976 @default.
- W4387035933 cites W2617219912 @default.
- W4387035933 cites W2618987161 @default.
- W4387035933 cites W2619984498 @default.
- W4387035933 cites W2651454156 @default.
- W4387035933 cites W2737565163 @default.
- W4387035933 cites W2763602017 @default.
- W4387035933 cites W2784007709 @default.
- W4387035933 cites W2790386468 @default.
- W4387035933 cites W2795880430 @default.
- W4387035933 cites W2889050653 @default.